The 2022–23 season was the 77th season in the history of UC Sampdoria and their 11th consecutive season in the top flight. The club participated in Serie A and the Coppa Italia.
Source: Serie A Rules for classification: 1) Points; 2) Tiebreaker for Champions team and third relegated team;[2] 3) Head-to-head points; 4) Head-to-head goal difference; 5) Goal difference; 6) Goals scored; 7) Draw. (Note: Head-to-head record is used only after all the matches between the teams in question have been played)[3] (O) Play-off winners; (R) Relegated Notes:
^ abThe Sampdoria squad was divided into two teams for an in-house friendly, with team A playing in blue colours and team B playing in white colours.
^Should the first and second, or 17th and 18th-placed teams at the end of the season be tied on points, a play-off tiebreaker match was held at a neutral site to determine the title and final team relegated respectively.
^"Prima Squadra" (in Italian). U.C. Sampdoria. Retrieved 16 August 2018.
^Should the first and second, or 17th and 18th-placed teams at the end of the season be tied on points, a play-off tiebreaker match was held at a neutral site to determine the title and final team relegated respectively.