Audressein is situated on the former Route nationale 618, the "Route of the Pyrenees", at the start of the climb to the Col de la Core some 18 km south-west of Saint-Girons. Access to the commune is by the D618 road from Argein in the west which passes through the centre of the commune and the village and continues to Engomer in the north-east. The D804 goes from Sor in the west through the commune just south of the village and continues to Castillon-en-Couserans in the south-east. The commune is mixed forest and farmland with substantial forests in the north.[3]
The Léz river flows through the commune from south to north forming the south-eastern border of the commune and continues north-east to join the Salat at Saint-Girons. The Bouigane river flows from the west across the commune to join the Lez at the village. The Long Rieu stream rises in the north of the commune and flows south to join the Bouigane near the village.[3]
The commune has one religious building that is registered as an historical monument:
The Church of Notre-Dame-de-Tramesaygues (14th century).[10] The church is listed as a World Heritage Site on the Routes of Santiago de Compostela. The original porch had three entries and a Bell tower from the 14th century. The church contains several items that are registered as historical objects: