DCP1A
Protein found in humans
mRNA-decapping enzyme 1A is a protein that in humans is encoded by the DCP1A gene .[ 5]
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.[ 5]
Interactions
DCP1A has been shown to interact with DCP2 [ 6] UPF1 .[ 6] GW182 , and other markers of P-body .[ 7] [ 8] [ 9] Arabidopsis thaliana homolog interacts with the plant specific type XI myosin motor protein.[ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000272886 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021962 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae)" .^ a b Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . ^ Eystathioy T, Jakymiw A, Chan EK, Séraphin B, Cougot N, Fritzler MJ (October 2003). "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies" . RNA . 9 (10): 1171–1173. doi :10.1261/rna.5810203 . PMC 1370480 PMID 13130130 . ^ Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, et al. (December 2009). "DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa" . Proceedings of the National Academy of Sciences of the United States of America . 106 (51): 21591–21596. Bibcode :2009PNAS..10621591T . doi :10.1073/pnas.0909871106 PMC 2789166 PMID 19966221 . ^ Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, et al. (December 2007). "A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting" . Molecular and Cellular Biology . 27 (24): 8600–8611. doi :10.1128/MCB.01506-07 . PMC 2169425 PMID 17923697 . ^ Steffens A, Jaegle B, Tresch A, Hülskamp M, Jakoby M (April 2014). "Processing-body movement in Arabidopsis depends on an interaction between myosins and DECAPPING PROTEIN1" . Plant Physiology . 164 (4): 1879–1892. doi :10.1104/pp.113.233031 PMC 3982750 PMID 24525673 .
Further reading
Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C, Duyster J (March 2002). "SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling". Nature Cell Biology . 4 (3): 181–190. doi :10.1038/ncb753 . PMID 11836524 . S2CID 19938060 . Callebaut I (May 2002). "An EVH1/WH1 domain as a key actor in TGFbeta signalling" . FEBS Letters . 519 (1–3): 178–180. doi :10.1016/S0014-5793(02)02751-5 PMID 12023040 . S2CID 84499961 . Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay" . Molecular and Cellular Biology . 22 (23): 8114–8121. doi :10.1128/MCB.22.23.8114-8121.2002 . PMC 134073 PMID 12417715 . Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci" . RNA . 8 (12): 1489–1501. doi :10.1017/S1355838202021726 . PMC 1370355 PMID 12515382 . Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications . 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 doi :10.1016/S0006-291X(03)01486-4 . PMID 12927788 . Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–1323. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130–12135. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (July 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies" . Nature Cell Biology . 7 (7): 719–723. doi :10.1038/ncb1274 . PMC 1855297 PMID 15937477 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (December 2005). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping" . Molecular Cell . 20 (6): 905–915. doi :10.1016/j.molcel.2005.10.031 PMID 16364915 . Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–648. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
