DXP reductoisomerase

1-deoxy-D-xylulose-5-phosphate reductoisomerase
crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose 5-phosphate
Identifiers
Symbol	DXP_reductoisom
Pfam	PF02670
Pfam clan	CL0063
InterPro	IPR013512
SCOP2	1onn / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

DXP reductoisomerase (1-deoxy-D-xylulose 5-phosphate reductoisomerase or DXR) is an enzyme that interconverts 1-deoxy-D-xylulose 5-phosphate (DXP) and 2-C-methyl-D-erythritol 4-phosphate (MEP).^[1]

• 
  1-Deoxy-D-xylulose 5-phosphate
• 
  2-C-methyl-D-erythritol 4-phosphate

It is classified under EC 1.1.1.267. It is normally abbreviated DXR, but it is sometimes named IspC, as the product of the ispC gene.

DXR is part of the MEP pathway (nonmevalonate pathway) of isoprenoid precursor biosynthesis. DXR is inhibited by fosmidomycin.

This enzyme is required for terpenoid biosynthesis in some organisms, since it is a key enzyme on the MEP pathway for the production of the isoprenoid precursors IPP and DMAPP.^[1] In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the MEP pathway for isoprenoid precursor biosynthesis. The enzyme requires Mn²⁺, Co²⁺ or Mg²⁺ for activity, with Mn²⁺ being most effective.

• DXP+reductoisomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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