GSPT2

GSPT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3KUJ
Identifiers
Aliases	GSPT2, ERF3B, GST2, G1 to S phase transition 2
External IDs	OMIM: 300418; MGI: 1316727; HomoloGene: 99786; GeneCards: GSPT2; OMA:GSPT2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	51,746,232 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	93,686,850 bp
RNA expression pattern
	Top expressed in
	sperm; ; germinal epithelium; ; Epithelium of choroid plexus; ; ventricular zone; ; gonad; ; ganglionic eminence; ; Brodmann area 23; ; middle temporal gyrus; ; retinal pigment epithelium; ; hair follicle;
	Top expressed in
	seminal vesicula; ; primary oocyte; ; zygote; ; secondary oocyte; ; dorsomedial hypothalamic nucleus; ; suprachiasmatic nucleus; ; efferent ductule; ; ventromedial nucleus; ; subiculum; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; translation release factor activity; protein binding; GTPase activity; RNA binding;
Cellular component	cytoplasm; cytosol; translation release factor complex;
Biological process	translational termination; cell cycle; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; cytoplasmic translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	23708
	14853
	ENSG00000189369
	ENSMUSG00000071723
	Q8IYD1
	Q149F3
	NM_018094
	NM_008179
	NP_060564
	NP_032205
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B is an enzyme that in humans is encoded by the GSPT2 gene.^[5]^[6]

GSPT2 is closely related to GSPT1 (MIM 139259), a GTP-binding protein that plays an essential role at the G1- to S-phase transition of the cell cycle in yeast and human cells. GSPT1 is a positive regulator of translational accuracy and, in a binary complex with eRF1 (MIM 600285), functions as a polypeptide chain release factor.[supplied by OMIM]^[6]

Interactions

GSPT2 has been shown to interact with PABPC1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000189369 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071723 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hansen LL, Jakobsen CG, Justesen J (Jan 2000). "Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping". Cytogenet Cell Genet. 86 (3–4): 250–1. doi:10.1159/000015353. PMID 10575220. S2CID 44348876.
^ ^a ^b "Entrez Gene: GSPT2 G1 to S phase transition 2".
^ Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T (Jun 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. 274 (24). UNITED STATES: 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005.

External links

Overview of all the structural information available in the PDB for UniProt: Q8IYD1 (Human Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)) at the PDBe-KB.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000189369 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000071723 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10575220-5] Hansen LL, Jakobsen CG, Justesen J (Jan 2000). "Assignment of the human peptide chain release factor 3 (GSPT2) to Xp11.23→p11.21 and of the distal marker DXS1039 by radiation hybrid mapping". Cytogenet Cell Genet. 86 (3–4): 250–1. doi:10.1159/000015353. PMID 10575220. S2CID 44348876.

[entrez-6] "Entrez Gene: GSPT2 G1 to S phase transition 2".

[pmid10358005-7] Hoshino S, Imai M, Kobayashi T, Uchida N, Katada T (Jun 1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein". J. Biol. Chem. 274 (24). UNITED STATES: 16677–80. doi:10.1074/jbc.274.24.16677. ISSN 0021-9258. PMID 10358005.

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GSPT2

Interactions

References

Further reading

External links