Idalopirdine

Idalopirdine
Clinical data
Other names	Lu-AE-58054
ATC code	None;
Identifiers
	IUPAC name 2-(6-Fluoro-1H-indol-3-yl)-N-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)ethanamine;
CAS Number	467459-31-0 ;
PubChem CID	21071390;
ChemSpider	19878969 ;
UNII	59WCJ0YNWM;
KEGG	D10710 ;
ChEMBL	ChEMBL3286580;
CompTox Dashboard (EPA)	DTXSID201026015 ;
ECHA InfoCard	100.245.270
Chemical and physical data
Formula	C20H19F5N2O
Molar mass	398.377 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)C(F)(F)COc1cccc(c1)CNCCc3c[nH]c2cc(F)ccc23;
	InChI InChI=1S/C20H19F5N2O/c21-15-4-5-17-14(11-27-18(17)9-15)6-7-26-10-13-2-1-3-16(8-13)28-12-20(24,25)19(22)23/h1-5,8-9,11,19,26-27H,6-7,10,12H2 ; Key:YBAWYTYNMZWMMJ-UHFFFAOYSA-N ;
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Idalopirdine (INN) (code names Lu AE58054,) is a potent and selective 5-HT₆ receptor antagonist under development by Lundbeck as an augmentation therapy for the treatment of cognitive deficits associated with Alzheimer's disease and schizophrenia.^[1]^[2] As of October 2013 it is in phase III clinical trials.^[2]

A phase III trial of two different daily doses of Lu AE58054 on top of 10 mg of donepezil for mild-to-moderate Alzheimer's failed to meet its primary endpoint with either dose.^[3] Two further phase III trials failed too, the company confirmed in early 2017.^[3]

References

^ "U.S. Development Programs". Lundbeck.
^ ^a ^b "Search of: Lu AE58054 - List Results". ClinicalTrials.gov. National Library of Medicine, U.S. Department of Health and Human Services.
^ ^a ^b Taylor NP (23 September 2016). "PhIII Alzheimer's flop takes chunk out of Lundbeck, hits Axovant with aftershocks".

External links

[urlU.S._Development_Programs._-_Lundbeck-1] "U.S. Development Programs". Lundbeck.

[urlSearch_of:_Lu_AE58054_-_List_Results_-_ClinicalTrials.gov-2] "Search of: Lu AE58054 - List Results". ClinicalTrials.gov. National Library of Medicine, U.S. Department of Health and Human Services.

[Taylor-fb-3] Taylor NP (23 September 2016). "PhIII Alzheimer's flop takes chunk out of Lundbeck, hits Axovant with aftershocks".

[1]

[2]

[3]

Idalopirdine

See also

References

External links