Integrin alpha 10

ITGA10
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1PT6, 1QC5, 1QCY, 2L8S, 2M32, 4A0Q
Identifiers
Aliases	ITGA10, PRO827, integrin subunit alpha 10
External IDs	OMIM: 604042; MGI: 2153482; HomoloGene: 2697; GeneCards: ITGA10; OMA:ITGA10 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	145,910,111 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	96,571,835 bp
RNA expression pattern
	Top expressed in
	tibia; ; Descending thoracic aorta; ; cartilage tissue; ; ascending aorta; ; right coronary artery; ; Achilles tendon; ; gastric mucosa; ; periodontal fiber; ; left coronary artery; ; right lung;
	Top expressed in
	facial skeleton; ; calvaria; ; Dermatocranium; ; membranous bone; ; mandible; ; sphenoid bone; ; fossa; ; maxilla; ; basisphenoid; ; body of femur;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; collagen binding involved in cell-matrix adhesion; collagen binding;
Cellular component	integrin complex; plasma membrane; membrane; integrin alpha10-beta1 complex; integral component of membrane;
Biological process	cell-matrix adhesion; extracellular matrix organization; cell adhesion; integrin-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8515
	213119
	ENSG00000143127
	ENSMUSG00000090210
	O75578
	n/a
	NM_001303040; NM_001303041; NM_003637
	NM_001081053; NM_001302471
	NP_001289969; NP_001289970; NP_003628
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene.^[5]^[6]^[7]

Function

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143127 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090210 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ITGA10 integrin, alpha 10".
^ Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383. PMID 9685391.
^ Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405.
^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

External links

ITGA10 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143127 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090210 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ITGA10 integrin, alpha 10".

[pmid9685391-6] Camper L, Hellman U, Lundgren-Akerlund E (August 1998). "Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes". J. Biol. Chem. 273 (32): 20383–9. doi:10.1074/jbc.273.32.20383. PMID 9685391.

[pmid10702680-7] Lehnert K, Ni J, Leung E, Gough S, Morris CM, Liu D, Wang SX, Langley R, Krissansen GW (1999). "The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization". Cytogenet. Cell Genet. 87 (3–4): 238–44. doi:10.1159/000015434. PMID 10702680. S2CID 85257405.

[pmid17236129-8] Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex Inheritance Pattern Resembling Autosomal Recessive Inheritance Involving a Microdeletion in Thrombocytopenia–Absent Radius Syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342. PMID 17236129.

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Integrin alpha 10

Function

Related gene problems

References

Further reading

External links