Cusack was born on October 11, 1962, in New York City and was raised in Evanston, Illinois.[3] Her mother, Ann Paula "Nancy" Cusack (née Carolan; 1929–2022),[4] was a former mathematics teacher and political activist.[5][6][7] Her father, Dick Cusack (1925–2003), was an actor and filmmaker, and two of her four siblings, Ann and John, are actors. Her family is of Irish Catholic descent.[8] Cusack is an alumna of the University of Wisconsin–Madison (1984).[9]
In the film Addams Family Values (1993), she played psychotic serial killer Debbie Jellinsky, who marries and kills rich men. She also starred in the short-lived ABC sitcom What About Joan? in 2001 and the hit film Arlington Road (1999). For many years, Cusack was also the commercial spokeswoman for U.S. Cellular. One of Cusack's most well-known roles was the principal of Horace Green Elementary School, Rosalie 'Roz' Mullins, in School of Rock (2003). She also voiced Jessie in the Pixar hits Toy Story 2 (1999), Toy Story 3 (2010), and Toy Story 4 (2019), and played Dr. Burton, the therapist of Charlie (Logan Lerman), in the teen film The Perks of Being a Wallflower (2012). She also played Erin's mom in the final episode of NBC's The Office.
Cusack was a cast member on the NBC sketch show Saturday Night Live from 1985 to 1986. Her recurring characters on SNL included Salena, a socially inept girl who tries to ask out her boyfriend, Biff (played by Jon Lovitz), who is also socially inept. In addition, she did celebrity impersonations of Brooke Shields, Jane Fonda, and Queen Elizabeth II.
In 2010, Cusack joined the Showtime drama/comedy Shameless as Sheila Jackson, the mother of Karen Jackson (Laura Slade Wiggins). The first season premiered on January 9, 2011, and had its first finale March 27, 2011. Cusack replaced actress Allison Janney, who portrayed the role in the first edit of the pilot episode. Janney took the role with the understanding the character would be less prominent on the show, but when producers decided to increase the character's screen presence, she was forced to pull out of the part to honor her series commitment on the ABC comedy Mr. Sunshine. Cusack has received critical acclaim for her performance, receiving Primetime Emmy Award for Outstanding Guest Actress in a Drama Series nominations in 2011, 2012, and 2013, as well as a nomination for the Primetime Emmy Award for Outstanding Guest Actress in a Comedy Series in 2014 and 2015, winning in the later year.
Personal life
Cusack married attorney Richard Burke, President and CEO of Envoy Global, Inc. in 1996.[12][13] They have two sons: Dylan John and Miles.[14] She discovered she was pregnant with her first child on her first day of shooting the movie Mr. Wrong (1996). Cusack owns a home in Three Oaks Township, Michigan, and lives in Chicago, Illinois.