Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2gene.[3][4][5]
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][5]
Function
LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[6]
^Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H (Apr 2016). "LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins". Nature Microbiology. 1 (6): 16054. doi:10.1038/NMICROBIOL.2016.54. PMID27572839. S2CID25500253.
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Rojo S, Burshtyn DN, Long EO, Wagtmann N (1997). "Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells". J. Immunol. 158 (1): 9–12. doi:10.4049/jimmunol.158.1.9. PMID8977169.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)
