MAML2
Protein-coding gene in the species Homo sapiens
Mastermind-like protein 2 is a protein that in humans is encoded by the MAML2 gene .[ 3] [ 4] [ 5]
See also
Details on the activity of the N-terminal domain of Mastermind-like protein 2 may be found under MamL-1 .
References
^ a b c GRCh38: Ensembl release 89: ENSG00000184384 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (Oct 2002). "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors" . Mol Cell Biol . 22 (21): 7688–700. doi :10.1128/MCB.22.21.7688-7700.2002 . PMC 135662 PMID 12370315 . ^ Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M (Dec 2002). "Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling" . J Biol Chem . 277 (52): 50612–20. doi :10.1074/jbc.M209529200 PMID 12386158 . ^ "Entrez Gene: MAML2 mastermind-like 2 (Drosophila)" .
Further reading
Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 8 (2): 85–95. doi :10.1093/dnares/8.2.85 PMID 11347906 . Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway" . Nat. Genet . 33 (2): 208–13. doi :10.1038/ng1083 . PMID 12539049 . S2CID 23417795 . Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Exp. Cell Res . 292 (1): 21–8. doi :10.1016/j.yexcr.2003.09.007 . PMID 14720503 . Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes Chromosomes Cancer . 43 (2): 202–5. doi :10.1002/gcc.20168 . PMID 15729701 . S2CID 39267344 . Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD (2005). "Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation" . EMBO J . 24 (13): 2391–402. doi :10.1038/sj.emboj.7600719 . PMC 1173159 PMID 15961999 . Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (2007). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma" . Clin. Cancer Res . 12 (13): 3902–7. doi :10.1158/1078-0432.CCR-05-2376 PMID 16818685 . Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G (2007). "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas" . Genes Chromosomes Cancer . 46 (6): 559–63. doi :10.1002/gcc.20440 PMID 17334997 . S2CID 39594598 . Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK (2007). "CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior". Genes Chromosomes Cancer . 46 (7): 708–15. doi :10.1002/gcc.20458 . PMID 17437281 . S2CID 24634433 . Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T (2007). "Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23)" . Genes Chromosomes Cancer . 46 (9): 813–9. doi :10.1002/gcc.20467 PMID 17551948 . S2CID 42629564 .
