Captain Holling (Beery) is relieved of command of his ship after he suffers a nervous breakdown. His replacement, Captain Downey (Howard), takes over the liner just as it is about to be used for an experiment in remote control.
Professor Grimson (Lewis) has devised a system for controlling the ship from a land-based laboratory. However, as Grimson demonstrates the system, a rival group is listening in, hoping to use the device for its own purposes.
Leonard Maltin called the film an "intriguing but slow-paced B-picture" ;[4] while Allmovie called it "a rather nifty little science fiction-thriller/murder mystery from Poverty Row company Monogram ... Typical low-budget fare, Mystery Liner is nevertheless well photographed by Archie Stout and for the most part capably acted" ;[3] and TV Guide noted "a fine example of a well-made thriller created on the programmer assembly line...Veteran director William Nigh does a typically professional job with the few resources at his disposal and cinematographer Archie Stout (who would eventually win an Oscar for his work on John Ford's The Quiet Man, 1952) contributes some exceptional camerawork."[5]