NRCAM

NRCAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UEN, 1UEY
Identifiers
Aliases	NRCAM, neuronal cell adhesion molecule
External IDs	OMIM: 601581; MGI: 104750; HomoloGene: 21041; GeneCards: NRCAM; OMA:NRCAM - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	108,456,717 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	44,601,964 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; Brodmann area 23; ; middle temporal gyrus; ; primary visual cortex; ; Brodmann area 9; ; prefrontal cortex; ; superior frontal gyrus; ; entorhinal cortex; ; right frontal lobe; ; amygdala;
	Top expressed in
	epithelium of lens; ; dentate gyrus of hippocampal formation granule cell; ; subiculum; ; primary visual cortex; ; medial dorsal nucleus; ; superior frontal gyrus; ; prefrontal cortex; ; anterior amygdaloid area; ; median eminence; ; arcuate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; protein binding involved in heterotypic cell-cell adhesion; ankyrin binding;
Cellular component	integral component of membrane; cell projection; membrane; plasma membrane; synapse; integral component of plasma membrane; extracellular region; axon; neuron projection; axon initial segment; external side of plasma membrane; glutamatergic synapse; integral component of postsynaptic membrane; integral component of postsynaptic density membrane;
Biological process	protein localization; clustering of voltage-gated sodium channels; regulation of neuron projection development; regulation of axon extension; axonogenesis; heterotypic cell-cell adhesion; neuron migration; central nervous system development; cell adhesion; neuronal action potential propagation; angiogenesis; positive regulation of neuron differentiation; synapse assembly; axonal fasciculation; retinal ganglion cell axon guidance; axon guidance; cell-cell adhesion; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
	4897
	319504
	ENSG00000091129
	ENSMUSG00000020598
	Q92823
	Q810U4
NM_001037132; NM_001037133; NM_001193582; NM_001193583; NM_001193584;
	NM_005010
	NM_001146031; NM_176930
NP_001032209; NP_001180511; NP_001180512; NP_001180513; NP_005001;
	NP_001358048; NP_001358051; NP_001358052; NP_001358053; NP_001358054; NP_001358055; NP_001358056; NP_001358057; NP_001358058; NP_001358059; NP_001358060; NP_001358061; NP_001358062; NP_001358063; NP_001358064; NP_001358065; NP_001358066; NP_001358067; NP_001358068; NP_001358069; NP_001358070; NP_001358071; NP_001358072; NP_001358073; NP_001358074; NP_001358075; NP_001358076; NP_001358077; NP_001358078; NP_001358079; NP_001358080; NP_001358081; NP_001358082; NP_001358083; NP_001358084; NP_001358085; NP_001358086; NP_001358087; NP_001358088; NP_001358089; NP_001358090; NP_001358091; NP_001358092; NP_001358093; NP_001358094; NP_001358095; NP_001358096; NP_001358097; NP_001358098; NP_001358099; NP_001358100; NP_001358101; NP_001358102; NP_001358103; NP_001358104; NP_001358105; NP_001358106; NP_001358107; NP_001358108; NP_001358109; NP_001358110; NP_001358111
	NP_001139503; NP_795904
	Wikidata
View/Edit Human	View/Edit Mouse

Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene.^[5]^[6]

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism^[7] and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091129 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020598 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lane RP, Chen XN, Yamakawa K, Vielmetter J, Korenberg JR, Dreyer WJ (Dec 1996). "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31". Genomics. 35 (3): 456–65. doi:10.1006/geno.1996.0385. PMID 8812479.
^ ^a ^b "Entrez Gene: NRCAM neuronal cell adhesion molecule".
^ Marui T, Funatogawa I, Koishi S, et al. (2008). "Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism". Int J Neuropsychopharmacol. 12 (1): 1–10. doi:10.1017/S1461145708009127. PMID 18664314.