PF-592,379 is a drug developed by Pfizer which acts as a potent, selective and orally active agonist for the dopamineD3receptor, which was under development as a potential medication for the treatment of female sexual dysfunction and male erectile dysfunction. Unlike some other less selective D3 agonists, a research study showed that PF-592,379 has little abuse potential in animal studies, and so was selected for further development and potentially human clinical trials.[1][2]Development has since been discontinued.[3]
^Attkins N, Betts A, Hepworth D, Heatherington AC (November 2010). "Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 40 (11): 730–42. doi:10.3109/00498254.2010.514961. PMID20836725. S2CID30288414.
