During the summer session of the transfer market later that year, Juventus bought Lirola outright.[4] On 28 July 2016, he moved to Sassuolo on a two-year loan.[5][6]
Lirola made his official professional debut in the play-off round of the UEFA Europa League, assisting Domenico Berardi's goal in a 1–1 away draw against Red Star Belgrade, which enabled the club to qualify for the group stage of the competition for the first time in their history.[2] In the same competition, he scored the opening goal, the first of his career, in a 3–0 home win over Athletic Bilbao on 15 September, in the club's opening group match; this was the club's historic first ever goal in official European competitions.[7]
Sassuolo
On 31 January 2018, Sassuolo signed Lirola outright, for €7 million fee.[8]
Fiorentina
On 1 August 2019, Lirola joined Serie A side Fiorentina on loan with an obligation to buy.[9]
Marseille
On 12 January 2021, Lirola joined French side Marseille, on a loan until the end of the season.[10]
Loan to Elche
On 12 August 2022, Lirola moved to La Liga club Elche on loan with an option to buy.[11]