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Roche

For other uses, see Roche (disambiguation).

Roche Holding AG
Company typePublic
SIX: RO (voting)
SIX: ROG (non-voting)
ISINCH0012032048
IndustryPharmaceuticals
PredecessorHoffmann, Traub & Co. (1894)
Founded1 October 1896; 128 years ago (1896-10-01)
FounderFritz Hoffmann-La Roche
HeadquartersBasel, Switzerland
Area served
Worldwide
Key people
ProductsPharmaceuticals and diagnostics (List of products)
RevenueDecrease CHF 60.44 billion (2023)
Decrease CHF 15.39 billion (2023)
Decrease CHF 12.36 billion (2023)
Total assetsIncrease CHF 90.47 billion (2023)
Total equityIncrease CHF 33.26 billion (2023)
Number of employees
Decrease 103,605 (2023)
Subsidiaries
Websiteroche.com
Footnotes / references
[4]
Participation certificate of the F. Hoffmann-LaRoche & Co AG, issued 15 January 1932

F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational holding healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth-largest pharmaceutical company in the world by revenue[5] and the leading provider of cancer treatments globally.[6][7] In 2023, the company’s seat in Forbes Global 2000 was 76.[8]

The company owns the American biotechnology company Genentech, which is a wholly owned independent subsidiary, and the Japanese biotechnology company Chugai Pharmaceuticals, as well as the United States–based companies Ventana and Foundation Medicine. Roche's revenues during fiscal year 2020, were 58.32 billion Swiss francs. Descendants of the founding Hoffmann and Oeri families own slightly over half of the bearer shares with voting rights (a pool of family shareholders 45%, and Maja Oeri a further 5% apart), with Swiss pharma firm Novartis owning a further third of its shares until 2021. Roche is one of the few companies increasing their dividend every year, for 2020 as the 34th consecutive year.

F. Hoffmann-La Roche is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA).[9]47°33′31″N 7°36′22″E / 47.558624°N 7.606018°E / 47.558624; 7.606018

History

Founded in 1896 by Fritz Hoffmann-La Roche, the company was known early on for producing various vitamin preparations and derivatives.[10] In 1934, it became the first company to mass-produce synthetic vitamin C, under the brand name Redoxon. During the Second World War, Roche collaborated with the Nazi regime in Germany and used forced labour in its German and Polish-based factories.[11] They also moved all their Jewish employees to the United States to save them from Nazi attention.[12]

In 1957, Hoffmann-La Roche introduced the class of tranquilizers known as benzodiazepines (with Valium and Rohypnol being the best known members).[13] It manufactures and sells several cancer drugs and is a leader in this field. In 1956, the first antidepressant, iproniazid, was accidentally created during an experiment while synthesizing isoniazid. Originally, it had been intended to create a more efficient drug at combatting tuberculosis. Iproniazid, however, was revealed to have its own benefits; some people felt it made them feel happier. It was withdrawn from the market in the early 1960s due to toxic side-effects.

In 1976, an accident at a chemical factory in Seveso, Italy, owned by a subsidiary of Roche, caused a large dioxin contamination. In 1982, the United States arm of the company acquired Biomedical Reference Laboratories for US$163.5 million. That company dated from the late 1960s, and was located in Burlington, North Carolina. That year Hoffmann-La Roche then merged it with all of its laboratories, and incorporated the merged company as Roche Biomedical Laboratories, Inc. in Burlington. By the early 1990s, Roche Biomedical became one of the largest clinical laboratory networks in the United States, with 20 major laboratories and US$600 million in sales.[14]

Roche has also produced various HIV tests and antiretroviral drugs. It bought the patents for the polymerase chain reaction (PCR) technique in 1992. In 1995, the era of highly active anti-retroviral therapy (HAART) was initiated by the United States FDA's approval of Hoffman LaRoche's HIV protease inhibitor, saquinavir. Within 2 years of its approval (and that of ritonavir 4 months later) annual deaths from AIDS in the United States fell from over 50,000 to approximately 18,000.[15] On 28 April 1995, Hoffmann-La Roche sold Roche Biomedical Laboratories, Inc. to National Health Laboratories Holdings Inc. (which then changed its name to Laboratory Corporation of America Holdings).[16] Roche acquired Syntex in 1994, and Chugai Pharmaceuticals in 2002.

Oseltamivir an antiviral drug used to combat influenza. Roche is the only drug company authorized to manufacture the drug, which was discovered by Gilead Sciences. Roche purchased the rights to the drug in 1996, and in 2005, settled a royalty dispute, agreeing to pay Gilead tiered royalties of 14–22% of annual net sales without adjusting the payments for manufacturing costs, as had been allowed in the original licensing agreement.[17]

On 20 October 2005, Hoffmann-La Roche decided to license other companies to manufacture Oseltamivir.[18]

Also in 2005, Roche acquired the Swiss company GlycArt Biotechnology in order to acquire technology to afucosylate antibodies; one of its products in development was obinutuzumab, which gained FDA approval in November 2013 for the treatment of chronic lymphocytic leukemia.[19][20][21]

On 22 January 2008, Roche acquired Ventana Medical Systems for $3.4 billion.[22] On 2 January 2009, Roche acquired Memory Pharmaceuticals Corp.[23]

On 26 March 2009, Roche acquired Genentech for $46.8 billion.[24] On 12 March 2009, Roche agreed to fully acquire Genentech, in which it had held a majority stake since 1990,[25] after eight months of negotiations. As a result of the Genentech acquisition, Roche moved its Palo Alto–based research facilities to their campus that straddles the border between Clifton, New Jersey and Nutley, New Jersey while Roche's United States headquarters, located on the New Jersey site since 1929, was moved to Genentech's facility in South San Francisco.[26] Genentech became a wholly owned subsidiary group of Roche on 25 March 2009.[27] Roche began vacating the NJ site in 2012, and sold it off in 2016.[28]

Roche acquired Medingo Ltd. in April 2010, for $160 million[29] and BioImagene, Inc. in August for $100 million.[30]

In 2011, the company received the International Society for Pharmaceutical Engineering Facility of the Year Award for Process Innovation for Roche's "MyDose" Clinical Supply project.[31] In March 2011, Roche acquired PVT Probenverteiltechnik GmbH for up to €85 million.[32] In July 2010, Roche acquired mtm laboratories AG for up to 190 million EUR.[33] On October, Roche acquired Anadys Pharmaceuticals, Inc. for $230 million.[34] In December, Roche announced it would acquire Munich-based Verum Diagnostica GmbH, gaining entry to the fastest-growing field in the coagulation diagnostics market.[35]

On 26 June 2012, Roche announced the closure of the Nutley/Clifton campus, which was completed in 2013. The property is in the process of remediation.[36]

In July 2013, Roche Diagnostics acquired blood diagnostics company Constitution Medical Inc. for $220 million.[37] Later, in September, Genentech announced it would acquire Arrayit Corporation.[38]

On 7 April 2014, Roche announced its intention to acquire IQuum for up to $450 million,[39] as well as the rights to an experimental drug (ORY-1001) from Spanish company Oryzon Genomics for $21 million and up to $500 million in milestone payments.[40] On 2 June, Roche announced its intention to acquire Genia Technologies Inc. for up to $350 million.[41] In August 2014, the company agreed to purchase Californian-based pharmaceutical firm InterMune for $8.3 billion, at $74 a share this represents a 38% premium over the final share closing price,[42][43] as well as Santaris Pharma A/S for $450 million.[44] In December 2014, the company acquired next-generation sequencing processing company Bina Technologies for an undisclosed sum[45] and Dutalys GmbH[46] a developer of next-generation anti-bodies.[46]

On 16 January 2015, the company announced that they would acquire Trophos for €470 million ($543 million) in order to increase the company's neuromuscular disease presence. The deal will centre on the Phase II and III spinal muscular atrophy drug olesoxime (TRO19622).[47] In April 2015, Roche acquired CAPP Medical, and its chief development of technology for cancer screening and monitoring via the detection of circulating tumour DNA.[48]

In August, the company announced its intention to acquire GeneWEAVE, Inc. for up to $425 million in order to strengthen its microbial diagnostics business.[49] Days later the company acquired Kapa Biosystems, Inc. for $445M, focussing on next generation sequencing and polymerase chain reaction applications.[50] In October 2015, the company acquired Adheron Therapeutics for $105 million (plus up to $475 million in milestone payments).[51]

In January 2016, the company announced it would acquire Tensha Therapeutics for $115 million upfront, with $420 million in contingent payments.[52]

In January 2017, the company acquired ForSight VISION4.[53] In June, the company acquired the diabetes management platform, mySugr GmbH for an undisclosed price.[54] In November Roche acquired Viewics, Inc.[55] In late December the company announced it would acquire Ignyta Inc, expanding its global oncology business.[56]

In February 2018, Roche announced it would acquire Flatiron Health, a business specialising in US cancer data analytics, for $1.9 billion.[57][58] In June of the same year the company announced it would acquire the outstanding shares of Foundation Medicine for $2.4 billion ($137 per share).[59] Later in September Roche announced its intention to acquire Tusk Therapeutics for up to €655 million ($759 million) expanding Roche's oncology pipeline. Tusk announced that the anti-CD38 antibody it is developing will be spun off to form a new company, Black Belt Therapeutics.[60] In late November, the company announced that Genentech would acquire Jecure Therapeutics, gaining access to Jecure's portfolio of NLRP3 inhibitors developed to fight inflammatory diseases like non-alcoholic steatohepatitis and liver fibrosis.[61]

In February 2019, the business announced it would acquire gene therapy company, Spark Therapeutics, for US$4.3 billion ($114.50 per share) adding Spark's gene therapy portfolio to its previous acquired assets. Spark has an already approved treatment for Leber's congenital amaurosis, Luxturna – priced at US$850,000 per patient.[62] The offer to acquire Spark Therapeutics was extended to May 2019 after Roche was unable to garner majority support from Spark shareholders.[63] A second gene therapy-related action came in December with the US$1.15 billion acquisition of non-United States rights to an investigational duchenne muscular dystrophy gene therapy developed by Sarepta Therapeutics.[64] In November, Roche acquired Promedior and its lead treatment – PRM-151 – for the treatment of idiopathic pulmonary fibrosis, for $390 million upfront and another $1 billion in milestone payments.[65][66]

In March 2020, the Roche Diagnostics division reached a significant milestone with the FDA-approval of its high-volume Sars-CoV-2 diagnostic test, capable of analysing 1,400-8,800 samples within 24h on the proprietary Cobas 6800/8800 molecular testing system.[67] In May the company announced it had acquired US-based Stratos Genomics for an undisclosed amount.[68][69] In September, the business acquired Ireland-based Inflazome, for €380 million, gaining control of its NLRP3 inflammasome inhibitors.[70][71]

In March 2021, Roche announced it would acquire GenMark Diagnostics for $1.8 billion.[72][73] Under the terms of agreement, Genmark diagnostics will become a subsidiary and the principal operations will continue to remain in Carlsbad, California.[74] In September, the company announced it would acquire German biotech group, TIB Molbiol, enhancing its molecular diagnostics operations.[75]

In September 2022, Roche acquired Good Therapeutics at a cost of $250M for its PD1-regulated IL-2 receptor agonist program.[76][77]

In July 2023, Roche partnered with Alnylam Pharmaceuticals in a deal worth $2.8 billion for the development of a hypertension drug.[78] In December 2023, Roche acquired Carmot Therapeutics, an anti-obesity drug developer, for $2.7 billion.[79]

In October 2023, Monte Rosa Therapeutics and Roche signed a strategic cooperation and licensing agreement for the discovery and development of molecular adhesive degradators (MGD) to combat cancer and neurological diseases. The partnership includes Monte Rosa’s QuEENT discovery engine and Roche Holding expertise. Also Monte Rosa will receive $50m as an upfront payment and additional payments that will depend on the pre-clinical, clinical, commercial stages and sales, as well as multi-level royalty system and may exceed $2 billion.[80]

In March 2024, it was announced Roche had sold Genentech's site in Vacaville, California to the Swiss pharmaceutical company, Lonza for $1.2 billion.[81]

In November 2024, Roche acquired Poseida Therapeutics for US $1.0 billion.[82][83]

Family

The Hoffmann-La Roche family is Switzerland's richest and one of the most secretive families.[84] Many members of the family don't carry the last name Hoffmann anymore. Some are known as Oeri, Michalski, Faber-Castell, Fabre, Zivtins, Schmid or Duschmalé.[85]

Acquisition history

Roche acquisitions
  • Hoffmann-La Roche (Founded 1896 by Fritz Hoffmann-La Roche)
    • Biomedical Reference Laboratories (Acq 1982, restructured into Roche Biomedical Laboratories, Inc in 1982, sold 1995)
    • Syntex (Acq 1994)
    • Chugai Pharmaceuticals (Acq 2002)
    • 454 Life Sciences (Acq 2007)
    • Roche Diagnostics
      • Spring BioScience Corp (Acq 2007)
      • Ventana Medical Systems (Acq 2009)
      • mySugr GmbH (Acq 2017)
      • Viewics, Inc (Acq 2017)
      • Flatiron Health (Acq 2018)
      • Stratos Genomics (Acq 2020)
    • Memory Pharmaceuticals Corp (Acq 2009)
    • Genentech (Acq 2009)
      • Tanox, Inc (Acq 2006)
      • Arrayit Corporation (Acq 2013)
      • Seragon (Acq 2014)
      • Jecure Therapeutics (Acq 2018)
    • Medingo Ltd (Acq 2010)
    • BioImagene, Inc. (Acq 2010)
    • PVT Probenverteiltechnik GmbH (Acq 2010)
    • MTM laboratories AG (Acq 2010)
    • Anadys Pharmaceuticals, Inc. (Acq 2010)
    • Verum Diagnostica GmbH (Acq 2011)
    • Constitution Medical Inc. (Acq 2012)
    • IQuum (Acq 2014)
    • Genia Technologies Inc. (Acq 2014)
    • InterMune (Acq 2014)
    • Santaris Pharma A/S (Acq 2014)
    • Bina Technologies, Inc. (Acq 2014)
    • Dutalys GmbH (Acq 2014)
    • Ariosa Diagnostics (Acq 2014)
    • Trophos (Acq 2015)
    • CAPP Medical (Acq 2015)
    • GeneWEAVE BioSciences, Inc. (Acq 2015)
    • Kapa Biosystems, Inc. (Acq 2015)
    • Adheron Therapeutics (Acq 2015)
    • Tensha Therapeutics (Acq 2016)
    • ForSight VISION4 (Acq 2017)
    • Ignyta Inc (Acq 2017)
    • Foundation Medicine, Inc. (Acq 2018)
    • Tusk Therapeutics (Acq 2018)
    • Spark Therapeutics (Acq 2019)
    • Promedior (Acq 2019)
    • Stratos Genomics (Acq 2020)
    • Inflazome (Acq 2020)
    • GenMark Diagnostics (Acq 2021)
    • TIB Molbiol (Acq 2021)
    • Good Therapeutics (Acq 2022)[86]
    • Telavant (Acq 2023)[87]
    • Carmot Therapeutics (Acq 2023)

Financial data

Financial data in CHF billions[88][89][90]
Year 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022
Revenue 46.780 47.462 48.145 50.576 53.299 56.846 63.751 58.323 62.801 66.43
Net Income 11.164 9.332 8.863 9.576 8.633 10.865 14.108 15.068 14.935 13.53
Assets 62.167 75.641 75.763 76.819 76.676 78.517 83.091 86.138 92.317 88.15
Employees 85,080 88,509 91,747 94,052 93,734 94,442 97,735 101,238 100,920 103,613

Divisions

Roche has two major divisions: Pharmaceuticals and Diagnostics.

Roche Diagnostics manufactures diagnostic equipment and reagents for research and medical diagnostic applications. Internally, it is organised into five major business areas: Roche Applied Science, Roche Professional Diagnostics, Roche Diabetes Care, Roche Molecular Diagnostics and Roche Tissue Diagnostics (Ventana). The main location for Roche Professional Diagnostics is in Rotkreuz, Switzerland.[91]

All business areas except Roche Applied Science focus on health care applications, targeting either physicians, hospitals and clinics, or consumers. Applied Science targets research settings in academia and pharmaceutical and biotechnology industries.

Products

Hoffmann-La Roche develops drugs used for cancer treatment, against virus diseases and for treatment of metabolic diseases. The company is the world's largest spender in pharmaceutical R&D.[92]

Tamiflu box

Drugs produced by Roche include:[needs update][original research?][citation needed]

Diabetes management products under the Accu-Chek brand include blood glucose meter, test strips and insulin pumps, as well as diabetes management software.

Other products include:

Price-fixing conspiracy

See also: Cartel

Stanley Adams, Roche's World Product Manager in Basel, contacted the European Economic Community in 1973 with evidence that Roche had been breaking antitrust laws, engaging in price fixing and market sharing for vitamins with its competitors. Roche was fined accordingly, but a bungle on the part of the EEC allowed the company to discover that it was Adams who had blown the whistle. He was arrested for unauthorised disclosure — an offence under Swiss law — and imprisoned. His wife, having learnt that he might face decades in jail, committed suicide.[95]

In 1999 the firm pleaded guilty to participation in a worldwide conspiracy to raise and fix prices for vitamins sold in the US and globally. Hoffmann-La Roche paid $500 million in criminal fines to the United States.[95][96][97]

Controversies

During the Second World War, Roche was reported to have collaborated with the Nazi regime in Germany and used prisoners-of-war or foreign forced labour in its German and Polish-based factories.[11]

In 2008 the Association of the British Pharmaceutical Industry (ABPI) suspended Roche for six months for breaching their code of conduct.[98]

In 2013, Roche had to pay back SFr 3.2 billion to the Swiss tax authorities due to transfer mispricing.[citation needed]

Collaborative research

In addition to internal research and development activities F. Hoffmann-La Roche is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical safety assessment is the InnoMed PredTox.[99][100] The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.[101]

See also

References

  1. ^ "FDA Grants Roche Breakthrough Therapy Designation on Hemophilia Drug". BioPharm International. UBM. 19 April 2018. Archived from the original on 20 June 2018. Retrieved 20 April 2018.
  2. ^ "Executive Committee". Roche.com. F. Hoffmann-La Roche. Archived from the original on 18 April 2023. Retrieved 18 April 2023.
  3. ^ "Roche names new head of $13 billion diagnostics unit". Reuters. 12 December 2022. Archived from the original on 18 April 2023. Retrieved 18 April 2023.
  4. ^ "Finance Report 2021" (PDF). Roche Holding. 4 February 2024. Retrieved 24 August 2024.
  5. ^ McGlauflin, Paige (15 August 2022). "The world's 10 biggest pharmaceutical companies raked in over $700 billion in revenue in 2021". Fortune. Archived from the original on 17 August 2022.
  6. ^ "Top 10 Oncology Pharma Companies in the World | Market Research Blog". Market Research Reports® Inc. 17 May 2019. Archived from the original on 27 September 2022. Retrieved 18 October 2020.
  7. ^ "Top 20 pharma companies by oncology sales - Top Pharma List - PMLiVE". pmlive.com. 16 June 2014. Archived from the original on 21 August 2023. Retrieved 18 October 2020.
  8. ^ "The Global 2000 2023". Forbes. Archived from the original on 29 January 2024. Retrieved 7 February 2024.
  9. ^ "The Pharmaceutical Industry in Figures – 2008 Edition". European Federation of Pharmaceutical Industries and Associations (EFPIA). p. 49. Archived from the original on 16 September 2008. Retrieved 25 August 2008.
  10. ^ "Switzerland's Biggest Family Fortune Has Prospered for 124 Years". Bloomberg.com. 6 August 2020. Retrieved 16 March 2022.
  11. ^ a b "Chemical firms exploited Nazi links, probe found". 30 August 2001. Archived from the original on 6 February 2022. Retrieved 6 February 2022.
  12. ^ Leo Sternbach, 97; Invented Valium, Many Other Drugs by THOMAS H. MAUGH II OCT. 1, 2005 L.A. Times
  13. ^ HannahBlake (1 November 2012). "A history of Roche". pharmaphorum.com. Archived from the original on 25 April 2022. Retrieved 16 March 2022.
  14. ^ "Roche Biomedical Laboratories, Inc". FundingUniverse.com. Archived from the original on 22 January 2012. Retrieved 3 September 2007.
  15. ^ "HIV Surveillance --- United States, 1981—2008". Archived from the original on 9 November 2013. Retrieved 8 November 2013.
  16. ^ Laboratory Corp of America Holdings · 10-Q · For 3/31/95 Archived 21 September 2020 at the Wayback Machine, SECInfo.com, Filed On 5/15/95, SEC File 1-11353, Accession Number 920148-95-11
  17. ^ "Roche, Gilead End Tamiflu Feud". Red Herring. 16 November 2005. Archived from the original on 1 August 2020. Retrieved 5 April 2006.
  18. ^ Kher, Unmesh (19 October 2005). "Why Roche Released Tamiflu". Time. Archived from the original on 22 October 2005. Retrieved 22 May 2008.
  19. ^ "Roche - Roche acquires Swiss based GlycArt Biotechnology to strengthen expertise in therapeutic antibody research". roche.com. Archived from the original on 5 February 2015. Retrieved 29 April 2015.
  20. ^ Presentation: GlycArt Biotechnology AG From Inception to trade sale – and what happened after... by Dr. Joël Jean-Mairet. Brussels, March 31, 2011
  21. ^ Cameron, F; McCormack, PL (January 2014). "Obinutuzumab: first global approval". Drugs. 74 (1): 147–54. doi:10.1007/s40265-013-0167-3. PMID 24338113. S2CID 40983655.
  22. ^ "Roche buys Ventana". Archived from the original on 5 June 2014. Retrieved 2 June 2014.
  23. ^ Pollack, Andrew (12 March 2009). "Roche buys Memory Pharmaceuticals". The New York Times. Archived from the original on 6 August 2015. Retrieved 2 June 2014.
  24. ^ Pollack, Andrew (12 March 2009). "Roche buys Genentech". The New York Times. Archived from the original on 6 August 2015. Retrieved 2 June 2014.
  25. ^ Pollack, Andrew (5 February 1990). "Genentech-Roche Deal May Spur Similar Ties". The New York Times. Archived from the original on 4 September 2020. Retrieved 11 April 2009.
  26. ^ Bawden, Tom (13 March 2009). "Roche swallows Genentech in third large drugs deal". The Times. London. Archived from the original on 12 June 2011. Retrieved 11 April 2009.
  27. ^ Jucca, Lisa; Cage, Sam (26 March 2009). "Roche completes Genentech buy". Reuters. Archived from the original on 13 February 2023. Retrieved 11 April 2009.
  28. ^ Proctor, Owen (17 June 2017). "Ex-Roche campus reinvented as 'On3' science center". northjersey.com. Retrieved 30 August 2022.
  29. ^ "Roche buys Medingo". Archived from the original on 12 January 2014. Retrieved 2 June 2014.
  30. ^ "Roche buysBioImagene". Archived from the original on 5 June 2014. Retrieved 2 June 2014.
  31. ^ "2011 Facility of the Year Category winners". Archived from the original on 29 April 2014. Retrieved 28 June 2012.
  32. ^ "Roche buys PVT". Archived from the original on 5 June 2014. Retrieved 2 June 2014.
  33. ^ "Roche buys mtm labs". Archived from the original on 5 June 2014. Retrieved 2 June 2014.
  34. ^ "Roche buys Anadys". Archived from the original on 5 June 2014. Retrieved 2 June 2014.
  35. ^ "Roche Acquires Verum Diagnostica GmbH for €11 Million". BioSpace. Archived from the original on 13 February 2023. Retrieved 25 February 2019.
  36. ^ "Roche announces closure of Nutley, NJ site". Archived from the original on 18 May 2013. Retrieved 28 June 2012.
  37. ^ "Roche buys Constitution Medical". Archived from the original on 2 June 2014. Retrieved 2 June 2014.
  38. ^ "Genentech Purchases Arrayit Corporation Technology". BioSpace. Archived from the original on 13 February 2023. Retrieved 25 February 2019.
  39. ^ "Roche buys IQuum". Archived from the original on 2 June 2014. Retrieved 2 June 2014.
  40. ^ Copley, Caroline (7 April 2014). "Roche buys experimental drug rights from Oryson". Reuters. Retrieved 2 June 2014.
  41. ^ Mulier, Thomas (2 June 2014). "Roche buys Genia". Bloomberg. Archived from the original on 31 October 2014. Retrieved 2 June 2014.
  42. ^ Michelle Cortez (24 August 2014). "Roche Holding Agrees to Buy InterMune for $8.3 Billion". Bloomberg L.P. Archived from the original on 23 January 2015. Retrieved 7 March 2017.
  43. ^ "Roche pays 37% premium on shares for InterMune in US $8.3bn deal". San Francisco News.Net. 24 August 2014. Archived from the original on 26 August 2014. Retrieved 24 August 2014.
  44. ^ "Roche Bags Santaris Pharma A/S In Deal Worth $450 Million". BioSpace. Archived from the original on 22 September 2022. Retrieved 25 February 2019.
  45. ^ "Roche Acquires Big Data Platform Provider". GEN. 19 December 2014. Archived from the original on 25 December 2014. Retrieved 20 December 2014.
  46. ^ a b "Roche To Pay Up To $489 Million For Next-Gen Antibody Firm Dutalys". BioSpace. 19 December 2014. Archived from the original on 26 February 2019. Retrieved 28 November 2018.
  47. ^ "Roche to Buy Trophos for Up-to-$543M". GEN. 16 January 2015. Archived from the original on 18 January 2015. Retrieved 16 January 2015.
  48. ^ "Roche Grabs CAPP Medical, a "Liquid Biopsy" Startup Targeting Cancer". BioSpace. Archived from the original on 26 February 2019. Retrieved 25 February 2019.
  49. ^ "Roche to Acquire GeneWEAVE for Up-to $425M". GEN. 13 August 2015. Archived from the original on 15 August 2015. Retrieved 14 August 2015.
  50. ^ "Roche Acquires Genomic Tools Provider Kapa Biosystems". GEN. 19 August 2015. Archived from the original on 21 August 2015. Retrieved 19 August 2015.
  51. ^ "Roche to Acquire Adheron Therapeutics for $105 Upfront - GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business - GEN". GEN. 9 October 2015. Archived from the original on 19 March 2017. Retrieved 23 May 2017.
  52. ^ "Roche Acquires Tensha Therapeutics for $115M Upfront - GEN Genetic Engineering & Biotechnology News - Biotech from Bench to Business - GEN". GEN. 11 January 2016. Archived from the original on 5 November 2016. Retrieved 23 May 2017.
  53. ^ Inc., ForSight VISION4. "ForSight VISION4, Inc. Announces Acquisition by Roche" (Press release). PR Newswire. {{cite press release}}: |last= has generic name (help)CS1 maint: numeric names: authors list (link)
  54. ^ Miller, John (30 June 2017). "Roche buys diabetes app firm in digital health push". Reuters. Archived from the original on 30 June 2017.
  55. ^ "Roche Scoops Up Bay Area's Viewics Amid Diagnostic Data Push". BioSpace. Archived from the original on 22 September 2022. Retrieved 25 February 2019.
  56. ^ "Roche to buy U.S. cancer drugmaker Ignyta for $1.7 billion". Reuters.com. Reuters. 22 December 2017. Archived from the original on 6 December 2018.
  57. ^ Dye, Jessica (15 February 2018). "Roche pays $1.9bn for Alphabet-backed Flatiron Health". Financial Times. Archived from the original on 10 December 2022.
  58. ^ "Roche to buy Flatiron Health for $1.9 billion to expand cancer care..." Reuters.com. Reuters. 15 February 2018. Archived from the original on 9 December 2018.
  59. ^ "Roche pays $2.4 billion for rest of cancer expert Foundation Medicine". Reuters.com. Reuters. 19 June 2018. Archived from the original on 9 December 2018.
  60. ^ "Roche Acquires Cancer Immunotherapy Developer Tusk Therapeutics". 28 September 2018. Archived from the original on 26 February 2019. Retrieved 25 February 2019.
  61. ^ "Roche buys U.S. biotech Jecure in race for liver disease drugs". Reuters.com. Reuters. 27 November 2018. Archived from the original on 28 November 2018.
  62. ^ "Roche 'steps up' for gene therapy with $4.3 billion Spark bet". Reuters.com. Reuters. 25 February 2019. Archived from the original on 25 February 2019.
  63. ^ "Roche says its $4.3 billion offer for Spark is still on track for June completion". CNBC. 3 April 2019. Archived from the original on 10 April 2019. Retrieved 10 April 2019.
  64. ^ Koltrowitz, Silke; Nadeem, Dania (23 December 2019). "Roche dives deeper into gene therapy with $1.15 billion Sarepta licensing deal". Reuters. Archived from the original on 23 December 2019. Retrieved 24 December 2019.
  65. ^ "Roche to Acquire Fibrosis-Focused Promedior for up to $1.4 Billion". 15 November 2019.
  66. ^ "Promedior Enters into Definitive Merger Agreement to be Acquired by Roche". 15 November 2019.
  67. ^ Hale C. (March 2020). "FDA grants Roche coronavirus test emergency green light within 24 hours" Archived 14 March 2020 at the Wayback Machine FierceBiotech. Retrieved 13 March 2020.
  68. ^ "Roche buys U.S. Gene sequencing tech company Stratos Genomics". Reuters. 22 May 2020. Archived from the original on 22 May 2020.
  69. ^ "Roche acquires Stratos Genomics to further develop DNA based sequencing for diagnostic use". Archived from the original on 7 June 2020. Retrieved 22 May 2020.
  70. ^ "Roche Dives into NLRP3 Inflammasome Inhibition with Acquisition of Inflazome". BioSpace. 21 September 2020. Archived from the original on 8 October 2020. Retrieved 22 September 2020.
  71. ^ "Inflazome Announces Acquisition by Roche". BioSpace. Archived from the original on 22 September 2022. Retrieved 3 January 2021.
  72. ^ "Roche Bolsters Diagnostics Pipeline with $1.8 Billion Buy of GenMark". 15 March 2021. Archived from the original on 25 April 2022. Retrieved 15 March 2021.
  73. ^ "Roche buys GenMark for $1.8 million to challenge test rivals". Reuters. 15 March 2021. Archived from the original on 13 February 2023.
  74. ^ "Roche signs definitive merger agreement with GenMark Diagnostics, Inc., to access novel technology to test for broad range of pathogens with one patient sample". Archived from the original on 28 April 2021. Retrieved 2 May 2021.
  75. ^ "Roche Holding to buy TIB Molbiol to enhance molecular diagnostics". Reuters. 9 September 2021.
  76. ^ "Good Therapeutics Announces Acquisition of Conditionally Active PD-1-regulated IL-2 Program by Roche". www.businesswire.com. 7 September 2022. Archived from the original on 17 July 2023. Retrieved 17 July 2023.
  77. ^ Garde, Damian (7 September 2022). "Roche pays $250 million to acquire Good Therapeutics and its preclinical cancer therapy". STAT. Archived from the original on 17 July 2023. Retrieved 17 July 2023.
  78. ^ "Roche Signs $2.8 Billion Alnylam Deal for Hypertension Drug". Bloomberg.com. 24 July 2023. Retrieved 25 July 2023.
  79. ^ "Roche enters obesity market with Carmot takeover but drugs may not be available until 2030". CNBC. 4 December 2023. Retrieved 8 December 2023.
  80. ^ "Monte Rosa and Roche partner for development of MGDs". Pharmaceutical Technology. 18 October 2023. Archived from the original on 28 October 2023. Retrieved 27 February 2024.
  81. ^ "Lonza to acquire biologics site in Vacaville, US from Roche for $1.2bn - Pharmafile". pharmafile.com. 20 March 2024. Retrieved 20 March 2024.
  82. ^ "Roche enters into a definitive agreement to acquire Poseida Therapeutics, including cell therapy candidates and related platform technologies". www.roche.com. Retrieved 26 November 2024.
  83. ^ "Roche to buy cell therapy developer Poseida for $1B". BioPharma Dive. Retrieved 26 November 2024.
  84. ^ "Switzerland's Biggest Family Fortune Has Prospered for 124 Years". Bloomberg.com. 6 August 2020. Archived from the original on 10 September 2021. Retrieved 15 April 2022.
  85. ^ "Nachkomme und Verwaltungsrat Jörg Duschmalé: "Roche war immer da, seit ich ganz klein war"". 18 September 2021. Archived from the original on 9 July 2022. Retrieved 9 July 2022.
  86. ^ "Good Therapeutics Announces Acquisition of Conditionally Active PD-1-regulated IL-2 Program by Roche". Businesswire. September 2022. Retrieved 17 July 2023.
  87. ^ Burger, Ludwig; Revill, John (23 October 2023). "Roche buys U.S. rights to Roivant bowel disease drug in $7.1 billion deal". Reuters. Archived from the original on 1 November 2023. Retrieved 13 March 2024.
  88. ^ "Roche Holding Bilanz, Gewinn und Umsatz | Roche Holding Geschäftsbericht | 855167". wallstreet-online.de. Archived from the original on 5 November 2018. Retrieved 5 November 2018.
  89. ^ MarketScreener. "ROCHE HOLDING AG : Financial Data Forecasts Estimates and Expectations | ROG | CH0012032048 | MarketScreener". www.marketscreener.com. Retrieved 3 June 2020.
  90. ^ GmbH, finanzen net. "Roche Financials | Markets Insider". Business Insider. Archived from the original on 3 June 2020. Retrieved 3 June 2020.
  91. ^ "Financial Report 2021" (PDF). Roche Holding. 4 February 2022. Archived (PDF) from the original on 23 February 2022. Retrieved 5 April 2022.
  92. ^ Miller, John (19 December 2017). "Roche touts Swiss-led R&D unit after years in Genentech's shadow". Reuters. Archived from the original on 19 December 2017. Retrieved 19 December 2017.
  93. ^ "Roche stops selling acne drug Accutane". Reuters. 26 June 2009. Retrieved 23 February 2016.
  94. ^ "FDA approves Xolair® (omalizumab) for adults with nasal polyps". www.roche.com. Archived from the original on 7 October 2023. Retrieved 21 September 2023.
  95. ^ a b Mathiason, Nick (25 November 2001). "Blowing the final whistle". The Observer. Retrieved 30 September 2014.
  96. ^ Corporate Crime Reporter. Corporate Crime Reporter. Retrieved 2013-11-24.
  97. ^ "Cartel price announcements: The vitamins industry" (PDF). International Journal of Industrial Organization. 26. 2008.[permanent dead link‍]
  98. ^ "Roche is suspended from ABPI for "actions likely to bring discredit" on the industry" (PDF). BJM.
  99. ^ Mattes, William B. (2008). "Public Consortium Efforts in Toxicogenomics". In Mendrick, Donna L.; Mattes, William B. (eds.). Essential Concepts in Toxicogenomics. Methods in Molecular Biology. Vol. 460. pp. 221–238. doi:10.1007/978-1-60327-048-9_11. ISBN 978-1-58829-638-2. PMID 18449490.
  100. ^ "InnoMed PredTox Member Organizations". Archived from the original on 26 September 2008. Retrieved 2008-08-25.
  101. ^ Innovative Medicines Initiative. "IMI Call Topics 2008". IMI-GB-018v2-24042008-CallTopics.pdf. European Commission. Archived from the original on 15 October 2009. Retrieved 25 August 2008.

Further reading

  • Hans Conrad Peyer (1996) Roche – A Company History 1896–1996 Basel: Editiones Roche ISBN 3-907770-59-5
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