In 2000, prior to his graduation from Stanford, Botha became director of corporate development for PayPal. He moved on to vice-president of finance and was named CFO in September 2001. PayPal went public in February 2002, and was purchased by eBay in October 2002. Meg Whitman offered Botha the opportunity to stay on as CFO post-acquisition, but he left to join Sequoia Capital in January 2003.[6][7][8][9]
At Sequoia, Botha oversaw the firm's investment in YouTube, Instagram, and Square, among others.[10][11] He also helped to plan the acquisition of Xoom by PayPal.[10] In 2017, Botha took over lead responsibility for Sequoia's US operations from Jim Goetz.[12] In April 2022, Sequoia announced that, starting in July 2022, Botha would replace Doug Leone as Senior Steward of Sequoia's global brand and operations.[13]
Botha has led or co-led Sequoia's investments in several early and growth stage companies. As of 2022, his active investments include Ethos, Evernote, GenEdit, Landis, mmhmm, Pendulum, Skiff, Temporal Technologies, and The Org.[14]