Cabrilla arrived at Pearl Harbor on 30 August 1943, and on 12 September cleared on the first of eight war patrols. After a daring exploit in which four Filipinoguerrillas were taken off Negros Island, Cabrilla completed her patrol at Fremantle, Australia, her base for the next five patrols.
During her second patrol, Cabrilla laid mines in the Gulf of Siam, and sank her first Japanese merchantman, then returned to Fremantle to prepare for her third patrol, a reconnaissance of Sunda Strait. Her fourth and fifth patrols, off Makassar, and in the Celebes and Sulu Seas, found her again striking with telling results against Japanese merchant shipping.
The most successful of her patrols was the sixth, in the South China Sea, and off Luzon from 13 September to 25 October 1944. During this period, she sank a total of 24,557 tons of shipping, including a 10,059-ton tanker. Cabrilla made her seventh war patrol in vicious weather in the Kurile Islands of northern Japan, and her last patrol found her on lifeguard duty for aviators downed at sea while carrying out attacks on Japan.
Homeward-bound after 2 arduous years, Cabrilla cleared Fremantle on 31 August 1945 for the States. Following overhaul at Philadelphia, she sailed for the Canal Zone for exercises (19 February – 17 March 1946), then underwent pre-inactivation overhaul at Philadelphia. Cabrilla was placed out of commission in reserve on 7 August 1946 at the Atlantic Reserve Fleet, New London, CT, and laid up in the Atlantic Reserve Fleet.
Cabrilla was recommissioned and redesignated Auxiliary Submarine AGSS-288, in 1962. She was decommissioned on 30 June 1968 and simultaneously struck from the Naval Register. Cabrilla was subsequently designated to be a museum ship and temporarily opened as such at GalvestonTexas. However, delays in preparing a permanent berth and the poor material condition of the sub compelled the memorial organizers to exchange Cabrilla for the Gato-class submarine Cavalla. In January 1971 Cabrilla was returned to the Navy, which sold her for scrapping in April 1972.
Cabrilla received six battle stars for World War II service. Of her eight patrols, six were designated as "Successful War Patrols". She is credited with having sunk a total of 38,767 tons of shipping.
^ abcdefgBauer, K. Jack; Roberts, Stephen S. (1991). Register of Ships of the U.S. Navy, 1775-1990: Major Combatants. Westport, Connecticut: Greenwood Press. pp. 275–280. ISBN0-313-26202-0.