Nuño began the 2011 season pitching in independent baseball for the Washington Wild Things of the Frontier League, where he worked on his changeup. In six games with the Wild Things, Nuño recorded a 2.83 ERA with 34 strikeouts.
With Iván Nova on the disabled list, the Yankees promoted Nuño to the major leagues on April 27, 2013.[10] He made his major league debut on April 29, pitching three scoreless innings in relief.[11] On May 13, he made his second appearance, his first major league start, in the second game of a doubleheader against the Cleveland Indians.[12] Nuño pitched five scoreless innings and got his first career win.[13] The next day, the Yankees optioned Nuño to Scranton/Wilkes-Barre to activate Curtis Granderson from the disabled list.[14]
On May 17, 2013, Nuño was recalled back to the New York Yankees MLB roster, following an injury to Andy Pettitte that forced him to the 15-day disabled list. In a relief outing against the Baltimore Orioles on May 21, he recorded his first major league loss after surrendering a lead-off home run to Nate McLouth in the 10th inning. He was again optioned to Scranton/Wilkes-Barre on May 30, 2013. Nuño was placed on the disabled list in June and missed the remainder of the 2013 season.[15]
Nuño competed with Michael Pineda, David Phelps, and Adam Warren for the final spot in the Yankees' starting rotation during spring training in 2014.[16] Pineda won the final spot, and Nuño made the Yankees' Opening Day roster as a relief pitcher.[17] After pitching in relief in three games, Nuño made his first start of the 2014 season on April 20.[18] Nuño started 14 games for the Yankees, going 2–5 while allowing up 15 home runs in 78 innings.
Arizona Diamondbacks
On July 6, 2014, Nuño was traded to the Diamondbacks for pitcher Brandon McCarthy.[19] Nuño pitched to a 3.74 ERA as a member of the Diamondbacks' starting rotation, but did not win a game in 14 starts, going 0–7 with the Diamondbacks and finishing the year with a win–loss record of 2–12 and a 4.56 ERA in 28 starts.[20] Nuno began the 2015 season with the Reno Aces of the Triple–A Pacific Coast League. He was promoted to the majors on May 11 and made one appearance before he was optioned to Reno on May 16.[21]
Seattle Mariners
Nuño pitching for the Seattle Mariners
On June 3, 2015, the Diamondbacks traded Nuño and Mark Trumbo to the Seattle Mariners for catcher Welington Castillo, reliever Dominic Leone and prospects Gabby Guerrero and Jack Reinheimer.[22] Nuño pitched to a 1–4 record with a 5.08 ERA in ten games started, and a 1.91 ERA in 25 appearances as a relief pitcher.[23] When he won a start on September 9, it was his first major league victory since June 27, 2014, and he broke a string of 44 appearances and 20 starts without a win; his 20-start winless streak had been tied for the longest active streak without a win in the major league's with Atlanta's Shelby Miller.[24]
In 2016, the Mariners determined that they would use Nuño solely as a relief pitcher.[23] In 56 appearances, including one
start, he posted a 3.53 ERA in 58+2⁄3 innings.
Baltimore Orioles
On November 6, 2016, the Mariners traded Nuño to the Los Angeles Dodgers for catcher Carlos Ruiz.[25] Nuño and the Dodgers avoided salary arbitration on January 10, 2017, by agreeing to a one-year, $1.125 million contract.[26] On February 19, 2017, he was traded to the Baltimore Orioles for minor league pitcher Ryan Moseley.[27] He elected free agency on October 1, 2017.
Tampa Bay Rays
On November 7, 2017, Nuno signed a minor league deal with the Tampa Bay Rays.[citation needed] He began the 2018 season with the Durham Bulls of the International League, and was promoted to the major leagues in May.[28] Nuno ended the season with an earned run average of 1.64 in 33 innings (17 appearances) out of the bullpen.[29] He threw a slider 67.0% of the time, tops in MLB.[30] Nuño was removed from the 40–man roster on November 2, and sent outright to Durham.[31] He subsequently elected free agency the same day.[32]
Washington Nationals
On January 17, 2019, Nuño signed a minor league contract with the Washington Nationals that included an invitation to spring training.[33] He was released on May 27, 2019.
Tampa Bay Rays (second stint)
On June 3, 2019, the Rays signed Nuño to a minor league deal.[34] In 27 games for the Triple–A Durham Bulls, he recorded a 7.58 ERA with 33 strikeouts across 29+2⁄3 innings of work. Nuño became a free agent following the season on November 4.[35]
Toros de Tijuana
On February 18, 2020, Nuño signed with the Toros de Tijuana of the Mexican League. Nuño did not play in a game in 2020 due to the cancellation of the Mexican League season because of the COVID-19 pandemic.[36] Nuño recorded 11 scoreless innings in 2021 for Tijuana.
Los Angeles Dodgers
On June 1, 2021, Nuño signed a minor league contract with the Los Angeles Dodgers organization.[37] He pitched in 18 games (seven starts) for the Triple–A Oklahoma City Dodgers, with a 6–2 record and a 7.09 ERA.[38]
Toros de Tijuana (second stint)
On February 28, 2022, Nuño signed with the Toros de Tijuana of the Mexican League.[39] Nuño made seven appearances for Tijuana in 2022, logging a 1.35 ERA with 6 strikeouts in 6.2 innings pitched. On January 23, 2023, Nuño was released by Tijuana.[40]
Acereros de Monclova
On March 8, 2023, Nuño signed with the Acereros de Monclova of the Mexican League.[41] In 28 appearances for Monclova, he posted a stellar 0.86 ERA with 30 strikeouts in 31+1⁄3 innings pitched.[42]
Nuño re-signed with Monclova for the 2024 season. In 42 games 32.1 innings of relief he went 2-0 with a 3.06 ERA 27 strikeouts and 1 save.
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