Natali's directing debut came in 1997, when he directed Cube which he also co-wrote.[5] The film became a success worldwide, especially in Japan and France, grossing over $10 million in the latter country,[6] and breaking box office records for a Canadian film. At the 19th Genie Awards, the film received five nominations, and also won the award for Best Canadian First Feature at the Toronto International Film Festival. After this success, Natali went on to direct Cypher (2002) and Nothing (2003).[7]
Natali was nominated for the 4th Annual Splatcademy Awards under the category "Best Director" presented by Cadaver Lab for his work Splice.[13] In 2013 his series Darknet, an adaptation of the Japanese series Tori Hada, began airing on Super Channel in Canada. In 2014, he directed the episodes "Su-zakana" and "Naka-choko" of the second season of the crime drama series Hannibal and in 2015 the episodes "Antipasto", "Primavera" and "Secondo" of the third season of the same TV series.[14] in 2015, he also directed the second episode (entitled "Simon") of the first season of the American supernatural drama television series The Returned. In 2016, he directed the fourth episode ("Dissonance Theory") of the HBO series Westworld. In 2017, he directed the fifth episode ("Lemon Scented You") of the Starz series American Gods.
He directed a pilot for a new Tremors TV series starring Kevin Bacon reprising his role from the 1990 film but it was not picked up by SyFy as a series.[15]
^Riser, Troy (21 October 2005). "Interview: Vincenzo Natali: Turtles All The Way Down". the-trades.com. The Trades. Archived from the original on 15 May 2013. Retrieved 10 April 2011. There really weren't too many touchstones, literary or otherwise. Except Beckett. We do owe a small debt to the Theatre of the Absurd." "Yes. He's a huge influence. But we're very different kinds of directors.
^Stubbs, Phil (2005). "Vincenzo Natali on the making of Tideland". gilliamdreams.com. Dreams – The Terry Gilliam Fanzine. Retrieved 10 April 2011. Yes I have a new film called Nothing - which is a title that causes endless confusion. It was just released in Canada a few months ago. If there is a single film that I've done that owes a real debt to Terry, that's it actually.