DDX31
DEAD (Asp-Glu-Ala-Asp) kutijski polipeptid 31 , znan i kao DDX31 , je ljudski gen .[ 5]
DEAD-kutijski proteini, koje karakterizira konzervirani motivAsp-Glu-Ala-Asp (DEAD), pretpostavljene su RNK helikaze . Uključeni su u brojne ćelijske procese koji uključuju promjenu sekundarne strukture RNK , kao što su inicijacija translacija, jedarna i mitohondrijska orerada i sklapanje ribosoma i splajsosoma . Na osnovu njihovih obrazaca distribucije, vjeruje se da su neki članovi ove porodice proteina iz DEAD-kutije uključeni u embriogenezu , spermatogenezu i ćelijski rast i diobu . Ovaj gen kodira člana ove porodice. Funkcija ovog člana nije utvrđena. Alternativna prerada ovog gena generira dvije varijante transkripta .[ 5]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 851 aminokiselina , а molekulska težina 94.087 Da .[ 6]
10 20 30 40 50 MAPDLASQRH SESFPSVNSR PNVILPGREG RREGLPPGGG TRGSLVPTRP VPPSPAPLGT SPYSWSRSGP GRGGGAGSSR VPRGVPGPAV CAPGSLLHHA SPTQTMAAAD GSLFDNPRTF SRRPPAQASR QAKATKRKYQ ASSEAPPAKR RNETSFLPAK KTSVKETQRT FKGNAQKMFS PKKHSVSTSD RNQEERQCIK TSSLFKNNPD IPELHRPVVK QVQEKVFTSA AFHELGLHPH LISTINTVLK MSSMTSVQKQ SIPVLLEGRD ALVRSQTGSG KTLAYCIPVV QSLQAMESKI QRSDGPYALV LVPTRELALQ SFDTVQKLLK PFTWIVPGVL MGGEKRKSEK ARLRKGINIL ISTPGRLVDH IKSTKNIHFS RLRWLVFDEA DRILDLGFEK DITVILNAVN AECQKRQNVL LSATLTEGVT RLADISLHDP VSISVLDKSH DQLNPKDKAV QEVCPPPAGD KLDSFAIPES LKQHVTVVPS KLRLVCLAAF ILQKCKFEED QKMVVFFSSC ELVEFHYSLF LQTLLSSSGA PASGQLPSAS MRLKFLRLHG GMEQEERTAV FQEFSHSRRG VLLCTDVAAR GLDLPQVTWI VQYNAPSSPA EYIHRIGRTA RIGCHGSSLL ILAPSEAEYV NSLASHKINV SEIKMEDILC VLTRDDCFKG KRWGAQKSHA VGPQEIRERA TVLQTVFEDY VHSSERRVSW AKKALQSFIQ AYATYPRELK HIFHVRSLHL GHVAKSFGLR DAPRNLSALT RKKRKAHVKR PDLHKKTQSK HSLAEILRSE YSSGMEADIA KVKKQNAPGE PGGRPLQHSL QPTPCFGRGK TLKWRKTQKG VQRDSKTSQK V
Reference
Dopunska literatura
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