FAM49A
Član A porodice sa sličnošću sekvence 49 , znan i kao FAM49A , jest protein koji je kod ljudi kodiran genom FAM49A sa hromosoma 2 .[ 5]
Amiokiselininska sekvenca
Dužina polipeptidnog lanca je 323 aminokiseline , a molkekulska iežina 37.313 Da .[ 6]
10 20 30 40 50 MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILA DLQAYKGAGP EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE KALQSLLESL TCPPYTPTQH LEREQALAKE FAEILHFTLR FDELKMRNPA IQNDFSYYRR TISRNRINNM HLDIENEVNN EMANRMSLFY AEATPMLKTL SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR SRFTSEETLM FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN ALRFTTKHLN DESTSKQIRA MLQ
Gen
Fam49A se nalazi na ljudskom hromosomu 2, na poziciji 2p24.3. Ima 1512 parova baza u transkriptu referentne sekvence iRNK .[ 7]
Protein
Gen Fam49A proizvodi potein dužine 323 aminokiseline . Protein ima domene : ostaci 15-319 čine domen nepoznate funkcije (DUF1394, PF07159 ). Ostaci 67 → 281 čine natporodicu regije interaktivnog citoplazmatskog fragmenta fragilnog X , člana A porodice sa sličnošću sekvence 49.[ 8]
Reference
^ a b c GRCh38: Ensembl release 89: ENSG00000197872 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020589 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: FAM49A family with sequence similarity 49, member A" .^ "UniProt, Q9H0Q0" (jezik: engleski). Pristupljeno 12. 11. 2021 .^ "Nucleotide - family with sequence similarity 49, member A [Homo sapiens]" . Nucleotide . National Center for Biotechnology Information, United States National Institutes of Health. Pristupljeno 9. 5. 2009 .^ "Protein - family with sequence similarity 49, member A [Homo sapiens]" . Protein . National Center for Biotechnology Information, United States National Institutes of Health. Pristupljeno 9. 5. 2009 .
Dopunska literatura
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8. doi :10.1093/nar/gkj139 . PMC 1347501 PMID 16381901 . Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 PMID 15489336 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 PMID 11256614 . Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 PMID 11230166 . Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 PMID 11076863 .
