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NDUFAF3

NDUFAF3
Identifikatori
AliasiNDUFAF3
Vanjski ID-jeviOMIM: 612911 MGI: 1913956 HomoloGene: 32460 GeneCards: NDUFAF3
Lokacija gena (čovjek)
Hromosom 3 (čovjek)
Hrom.Hromosom 3 (čovjek)[1]
Hromosom 3 (čovjek)
Genomska lokacija za NDUFAF3
Genomska lokacija za NDUFAF3
Bend3p21.31Početak49,020,459 bp[1]
Kraj49,023,495 bp[1]
Lokacija gena (miš)
Hromosom 9 (miš)
Hrom.Hromosom 9 (miš)[2]
Hromosom 9 (miš)
Genomska lokacija za NDUFAF3
Genomska lokacija za NDUFAF3
Bend9|9 F2Početak108,442,736 bp[2]
Kraj108,444,633 bp[2]
Obrazac RNK ekspresije
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija• GO:0001948, GO:0016582 vezivanje za proteine
Ćelijska komponenta• mitochondrial inner membrane
• membrana
• mitohondrija
• jedro
Biološki proces• mitochondrial respiratory chain complex I assembly
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez

25915

66706

Ensembl

ENSG00000178057

ENSMUSG00000070283

UniProt

Q9BU61

Q9JKL4

RefSeq (mRNK)

NM_199417
NM_199069
NM_199070
NM_199073
NM_199074

NM_023247

RefSeq (bjelančevina)

NP_951032
NP_951033
NP_951047
NP_951056

NP_075736

Lokacija (UCSC)Chr 3: 49.02 – 49.02 MbChr 9: 108.44 – 108.44 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

NK-protein prepoznavanja tumora jest protein koji je kod ljudi kodiran genom NKTR sa hromosoma 3.[5][6][7]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 1.462 aminokiseline, а molekulska težina 165.677 Da.[8]

1020304050
MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCSGEKGLG
KTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFI
LKHDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFEVI
EQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDS
SSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRN
KHAMNPKGHSERSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRD
MPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSC
SESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDPCSSRWDER
SLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRR
HKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDW
SKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSK
SRSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPV
VAENIPVIPLSDSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTY
SLANIKETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSR
SYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSD
DGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSE
SRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSE
RECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSK
NDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKS
SKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGK
KDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNET
IKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEE
NVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGN
ARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSAS
LASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKV
LTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDE
QTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRS
RSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSR
SYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYS
HHRSPSESSRYS

Funkcija

Ovaj gen kodira membranski usidreni protein sa hidrofobnim amino terminalnim domenom i ciklofilinskim domenom nalik PPIazama. Prisutan je na površini prirodnih ćelija ubica i olakšava njihovo vezivanje za mete. Njegova ekspresija regulirana je aktivacijom ćelija IL2.[7]

Reference

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000178057 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070283 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Young HA, Jenkins NA, Copeland NG, Simek S, Lerman MI, Zbar B, Glenn G, Ortaldo JR, Anderson SK (Jul 1993). "Localization of a novel natural killer triggering receptor locus to human chromosome 3p23-p21 and mouse chromosome 9". Genomics. 16 (2): 548–549. doi:10.1006/geno.1993.1229. PMID 8314596.
  6. ^ Chambers CA, Gallinger S, Anderson SK, Giardina S, Ortaldo JR, Hozumi N, Roder J (maj 1994). "Expression of the NK-TR gene is required for NK-like activity in human T cells". J Immunol. 152 (6): 2669–74. PMID 8144875.
  7. ^ a b "Entrez Gene: NKTR natural killer-tumor recognition sequence".
  8. ^ "UniProt, P30414" (jezik: engleski). Pristupljeno 4. 11. 2021.

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