RNR5

RNR5
Identifikatori
Aliasi	RNR5
Vanjski ID-jevi	OMIM: 180454 GeneCards: RNR5
Ortolozi
	6056
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	n; a
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	Wikipodaci
Pogledaj/uredi – čovjek

Ribosomska RNK 5, znana i kao RNR5, je ljudski gen na hromosomu 22.^[2]

Funkcija

Geni za ribosomnu RNK skupljeni su na kratkim kracima hromosoma 13, 14, 15, 20 i 21. Za gen RNR5 postoji u više kopija na hromosomu 22. Svaki klaster gena sadrži 30-40 kopija i kodira 45S RNK proizvod koji se zatim cijepa da formira podjedinice 18S, 5.8S i 28S rRNK. Općenito, geni za RNK ostaju slabo označeni u većini velikih javnih baza podataka.

Najbirnije regije za formiranje i organizaciju jedarceta nalaze se na kratkim (p) kracima hromosoma 13 14, 15, 21 i 22.

Reference

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RNR5 RNA, ribosomal 5".

Dopunska literatura

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Gonzalez IL, Chambers C, Gorski JL, et al. (1990). "Sequence and structure correlation of human ribosomal transcribed spacers". J. Mol. Biol. 212 (1): 27–35. doi:10.1016/0022-2836(90)90302-3. PMID 2319598.
Sylvester JE, Petersen R, Schmickel RD (1990). "Human ribosomal DNA: novel sequence organization in a 4.5-kb region upstream from the promoter". Gene. 84 (1): 193–196. doi:10.1016/0378-1119(89)90155-8. PMID 2606358.
La Volpe A, Simeone A, D'Esposito M, et al. (1985). "Molecular analysis of the heterogeneity region of the human ribosomal spacer". J. Mol. Biol. 183 (2): 213–223. doi:10.1016/0022-2836(85)90214-1. PMID 2989541.
Bartsch I, Schoneberg C, Grummt I (1987). "Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes". Mol. Cell. Biol. 7 (7): 2521–2529. doi:10.1128/mcb.7.7.2521. PMC 365386. PMID 3649563.
Haltiner MM, Smale ST, Tjian R (1987). "Two distinct promoter elements in the human rRNA gene identified by linker scanning mutagenesis". Mol. Cell. Biol. 6 (1): 227–235. doi:10.1128/mcb.6.1.227. PMC 367502. PMID 3785147.
Gonzalez IL, Gorski JL, Campen TJ, et al. (1985). "Variation among human 28S ribosomal RNA genes". Proc. Natl. Acad. Sci. U.S.A. 82 (22): 7666–7670. Bibcode:1985PNAS...82.7666G. doi:10.1073/pnas.82.22.7666. PMC 391394. PMID 3865188.
McCallum FS, Maden BE (1986). "Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates". Biochem. J. 232 (3): 725–733. doi:10.1042/bj2320725. PMC 1152944. PMID 4091818.
Financsek I, Mizumoto K, Mishima Y, Muramatsu M (1982). "Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes". Proc. Natl. Acad. Sci. U.S.A. 79 (10): 3092–3096. Bibcode:1982PNAS...79.3092F. doi:10.1073/pnas.79.10.3092. PMC 346359. PMID 6954460.
Gonzalez IL, Sylvester JE (1995). "Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer". Genomics. 27 (2): 320–328. doi:10.1006/geno.1995.1049. PMID 7557999.
Gonzalez IL, Sylvester JE (2001). "Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes". Genomics. 73 (3): 255–263. doi:10.1006/geno.2001.6540. PMID 11350117.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] "Entrez Gene: RNR5 RNA, ribosomal 5".

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