SCNN1G

SCNN1G
Identifikatori
Aliasi	SCNN1G
Vanjski ID-jevi	OMIM: 600761 MGI: 104695 HomoloGene: 20280 GeneCards: SCNN1G
Lokacija gena (čovjek)
Hrom.	Hromosom 16 (čovjek)
Kraj	23,216,883 bp
Lokacija gena (miš)
Hrom.	Hromosom 7 (miš)
Kraj	121,367,698 bp
Ontologija gena
Molekularna funkcija	• sodium channel activity; • ion channel activity; • GO:0001948, GO:0016582 vezivanje za proteine; • WW domain binding; • ligand-gated sodium channel activity;
Ćelijska komponenta	• integral component of membrane; • membrana; • sodium channel complex; • integral component of plasma membrane; • apical plasma membrane; • Egzosom; • external side of plasma membrane; • nukleoplazma; • ćelijska membrana;
Biološki proces	• izlučivanje; • sodium ion transmembrane transport; • response to stimulus; • sodium ion transport; • ion transport; • sodium ion homeostasis; • multicellular organismal water homeostasis; • sensory perception of taste; • ion transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	6340
	20278
	ENSG00000166828
	ENSMUSG00000000216
	P51170
	Q9WU39
	NM_001039
	NM_011326
	NP_001030
	NP_035456
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Gen SCNN1G kod kićmenjaka kodira podjedinicu γ epitelnog natrijevog kanala ENaC . ENaC je sastavljen kao heterotrimer od tri homologne podjedinice α, β i γ ili δ, β i γ. Ostale ENAC podjedinice su kodirane pomoću SCNN1A, SCNN1B i SCNN1D.^[5]

ENaC se eksprimira u epitelnim ćelijama i razlikuje se od naponski ovisnog natrijwvog kanala koji je uključen u stvaranje akcijskih potencijala u neuronima. Skraćenica za gene koji kodiraju za naponski natrijski kanal počinje sa tri slova: SCN. Za razliku od ovih natrijevih kanala, ENaC je konstitutivno aktivan i ne zavisi od napona. Drugo N u skraćenici (SCNN1) predstavlja da se radi o kanalima koji nisu naponski.

Kod većine kičmenjaka, ioni natrija su glavna determinanta osmolarnosti vanćelijske tečnosti.^[6] ENaC omogućava transfer iona natrija, preko epitelne ćelijske membrane u takozvanim "zategnutim epitelima" koji imaju nisku permeabilnost. Protok iona natrija kroz epitel utiče na osmolarnost vanćelijske tečnosti. Dakle, ENaC ima centralnu ulogu u regulaciji homeostaze tjelesnih tekućina i elektrolita i posljedično utiče na krvni pritisak.^[7]

Pošto amilorid snažno inhibira ENaC, on se takođe naziva "natrijevim kanalom osetljivim na amilorid".

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 649 aminokiselina, a molekulska masa 74.270 Da.^[5]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAPGEKIKAK	IKKNLPVTGP	QAPTIKELMR	WYCLNTNTHG	CRRIVVSRGR
LRRLLWIGFT	LTAVALILWQ	CALLVFSFYT	VSVSIKVHFR	KLDFPAVTIC
NINPYKYSTV	RHLLADLEQE	TREALKSLYG	FPESRKRREA	ESWNSVSEGK
QPRFSHRIPL	LIFDQDEKGK	ARDFFTGRKR	KVGGSIIHKA	SNVMHIESKQ
VVGFQLCSND	TSDCATYTFS	SGINAIQEWY	KLHYMNIMAQ	VPLEKKINMS
YSAEELLVTC	FFDGVSCDAR	NFTLFHHPMH	GNCYTFNNRE	NETILSTSMG
GSEYGLQVIL	YINEEEYNPF	LVSSTGAKVI	IHRQDEYPFV	EDVGTEIETA
MVTSIGMHLT	ESFKLSEPYS	QCTEDGSDVP	IRNIYNAAYS	LQICLHSCFQ
TKMVEKCGCA	QYSQPLPPAA	NYCNYQQHPN	WMYCYYQLHR	AFVQEELGCQ
SVCKEACSFK	EWTLTTSLAQ	WPSVVSEKWL	LPVLTWDQGR	QVNKKLNKTD
LAKLLIFYKD	LNQRSIMESP	ANSIEMLLSN	FGGQLGLWMS	CSVVCVIEII
EVFFIDFFSI	IARRQWQKAK	EWWAWKQAPP	CPEAPRSPQG	QDNPALDIDD
DLPTFNSALH	LPPALGTQVP	GTPPPKYNTL	RLERAFSNQL	TDTQMLDEL

Struktura gena

Dok se ljudski gen SCNN1A nalazi u hromosomskoj sekvenci 12p,^[8] ljudski geni koji kodiraju SCNN1B i SCNN1G nalaze se u jukstopoziciji u kratkom kraku hromosoma 16 (16p12-p13). Strukture ljudskih i pacovskih SCNN1G gena prvi su objavili Thomas et al.^[9]^[10] Kasnije studije Saxena et al. prijavile su kompletnu kodirajuću sekvencu ljudskog SCNN1G gena, utvrđujući da ima 13 egzona. Položaji introna su konzervirani u sva tri ljudska ENaC gena, SCNN1A, SCNN1B i SCNN1G.^[11] The positions of the introns are also highly conserved across vertebrates See: Ensembl GeneTree.

Egzon-intron struktura primarnog transkripta ljudskog SCNN1B. Broj svakog egzona je označen iznad njega. Iznad transkripta je prikazan redni broj transkripta. Klikom na sliku će čitatelj biti upućen na listu transkripata u bazi podataka Ensembl.

Struktura proteina

Primarne strukture sve četiri ENaC podjedinice pokazuju snažnu sličnost. Dakle, ova četiri proteina predstavljaju porodicu proteina koji imaju zajedničkog pretka. U globalnom poravnanju (što znači poravnanje sekvenci duž cele njihove dužine, a ne samo djelimičnog segmenta), ljudska γ podjedinica dijeli 34% identiteta sa β podjedinicom i 27 i 23% identiteta sa α i δ podjedinicama.

Sve četiri sekvence ENaC podjedinica imaju dva hidrofobna dijela koja formiraju dva transmembranska segmenta zvana TM1 i TM2.^[12]

Klinički značaj

Od nasljednih poremećaja ovog gene najozbiljniji je Liddleov sindrom. Općenito je uzrokovan mutacijama u PY motivu ili skraćenjem C-terminala, uključujući gubitak PY motiva u β ili γ ENaC podjedinicama.^[13]^[14]^[15]^[16]^[17]^[18] Iako postoji PY motiv također u α podjedinici, do sada Liddleova bolest nije uočena u vezi s mutacijom u α podjedinici. Liddleov sindrom se nasljeđuje kao autosomno dominantna bolest s fenotipom koji uključuje hipertenziju u ranom nastanku, metaboličku alkalozu i niske razine aktivnosti renina u plazmi i mineralokortikoidnog hormona aldosterona. U nedostatku prepoznatljivog PY motiva, ubikvitin-proteinska ligaza Nedd4-2 ne može se vezati za ENaC podjedinicu i stoga ne može vezati ubikvitin na nju. Posljedično, proteoliza ENaC proteasomom je inhibirana i ENaC se akumulira u membrani što dovodi do pojačane aktivnosti ENaC koja uzrokuje hipertenziju.^[19]^[20]^[21]^[22]

Interakcije

Pokazalo se da SCNN1G u interakciji sa:

Također pogledajte

Natrijski kanal

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166828 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000216 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Hanukoglu I, Hanukoglu A (Jan 2016). "Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases". Gene. 579 (2): 95–132. doi:10.1016/j.gene.2015.12.061. PMC 4756657. PMID 26772908.
^ Bourque CW (Jul 2008). "Central mechanisms of osmosensation and systemic osmoregulation". Nature Reviews. Neuroscience. 9 (7): 519–31. doi:10.1038/nrn2400. PMID 18509340. S2CID 205504313.
^ Rossier BC, Baker ME, Studer RA (Jan 2015). "Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited". Physiological Reviews. 95 (1): 297–340. doi:10.1152/physrev.00011.2014. PMID 25540145.
^ Ludwig M, Bolkenius U, Wickert L, Marynen P, Bidlingmaier F (May 1998). "Structural organisation of the gene encoding the alpha-subunit of the human amiloride-sensitive epithelial sodium channel". Human Genetics. 102 (5): 576–81. doi:10.1007/s004390050743. PMID 9654208. S2CID 22547152.
^ Thomas CP, Doggett NA, Fisher R, Stokes JB (Oct 1996). "Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel". Journal of Biological Chemistry. 271 (42): 26062–6. doi:10.1074/jbc.271.42.26062. PMID 8824247.
^ Thomas CP, Auerbach SD, Zhang C, Stokes JB (Mar 1999). "The structure of the rat amiloride-sensitive epithelial sodium channel gamma subunit gene and functional analysis of its promoter". Gene. 228 (1–2): 111–22. doi:10.1016/s0378-1119(99)00016-5. PMID 10072764.
^ Saxena A, Hanukoglu I, Strautnieks SS, Thompson RJ, Gardiner RM, Hanukoglu A (Nov 1998). "Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit". Biochemical and Biophysical Research Communications. 252 (1): 208–213. doi:10.1006/bbrc.1998.9625. PMID 9813171.
^ Canessa CM, Merillat AM, Rossier BC (Dec 1994). "Membrane topology of the epithelial sodium channel in intact cells". The American Journal of Physiology. 267 (6 Pt 1): C1682–90. doi:10.1152/ajpcell.1994.267.6.C1682. PMID 7810611.
^ Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP (1995). "Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome". Nat. Genet. 11 (1): 76–82. doi:10.1038/ng0995-76. PMID 7550319. S2CID 22106822.
^ Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW (1994). "Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel". Cell. 79 (3): 407–14. doi:10.1016/0092-8674(94)90250-X. PMID 7954808. S2CID 54282654.
^ Hansson JH, Schild L, Lu Y, Wilson TA, Gautschi I, Shimkets R, Nelson-Williams C, Rossier BC, Lifton RP (1996). "A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11495–9. doi:10.1073/pnas.92.25.11495. PMC 40428. PMID 8524790.
^ Inoue J, Iwaoka T, Tokunaga H, Takamune K, Naomi S, Araki M, Takahama K, Yamaguchi K, Tomita K (1998). "A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel". J. Clin. Endocrinol. Metab. 83 (6): 2210–3. doi:10.1210/jcem.83.6.5030. PMID 9626162.
^ Persu A, Barbry P, Bassilana F, Houot AM, Mengual R, Lazdunski M, Corvol P, Jeunemaitre X (1998). "Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension". Hypertension. 32 (1): 129–37. doi:10.1161/01.hyp.32.1.129. PMID 9674649.
^ Uehara Y, Sasaguri M, Kinoshita A, Tsuji E, Kiyose H, Taniguchi H, Noda K, Ideishi M, Inoue J, Tomita K, Arakawa K (1998). "Genetic analysis of the epithelial sodium channel in Liddle's syndrome". J. Hypertens. 16 (8): 1131–5. doi:10.1097/00004872-199816080-00008. PMID 9794716. S2CID 31393115.
^ Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ (1996). "Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel". Cell. 83 (6): 969–78. doi:10.1016/0092-8674(95)90212-0. PMID 8521520. S2CID 970556.
^ Tamura H, Schild L, Enomoto N, Matsui N, Marumo F, Rossier BC (1996). "Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene". J. Clin. Invest. 97 (7): 1780–4. doi:10.1172/JCI118606. PMC 507244. PMID 8601645.
^ Firsov D, Schild L, Gautschi I, Mérillat AM, Schneeberger E, Rossier BC (1997). "Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15370–5. doi:10.1073/pnas.93.26.15370. PMC 26411. PMID 8986818.
^ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
^ Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. 345 (3): 503–9. doi:10.1042/0264-6021:3450503. PMC 1220784. PMID 10642508.
^ McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. PMID 12167593.
^ Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.
^ Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER, Benos DJ (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. PMID 14996668. S2CID 18384316.
^ Boulkroun S, Ruffieux-Daidié D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. PMID 18632802.
^ Raikwar NS, Thomas CP (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. PMC 2424110. PMID 18322022.

Dopunska literatura

Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D (1998). "Regulation of stability and function of the epithelial Na⁺ channel (ENaC) by ubiquitination". EMBO J. 16 (21): 6325–36. doi:10.1093/emboj/16.21.6325. PMC 1170239. PMID 9351815.
Arai K, Zachman K, Shibasaki T, Chrousos GP (1999). "Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential?". J. Clin. Endocrinol. Metab. 84 (7): 2434–7. doi:10.1210/jcem.84.7.5857. PMID 10404817.
Auerbach SD, Loftus RW, Itani OA, Thomas CP (2000). "Human amiloride-sensitive epithelial Na⁺ channel gamma subunit promoter: functional analysis and identification of a polypurine-polypyrimidine tract with the potential for triplex DNA formation". Biochem. J. 347 (1): 105–14. doi:10.1042/0264-6021:3470105. PMC 1220937. PMID 10727408.
Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, Garty H (2002). "Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation". J. Biol. Chem. 277 (16): 13539–47. doi:10.1074/jbc.M111717200. PMID 11805112.

Vanjski linkovi

SCNN1G protein, human na US National Library of Medicine Medical Subject Headings (MeSH)

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166828 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000216 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2016-Hanukoglu-5] Hanukoglu I, Hanukoglu A (Jan 2016). "Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases". Gene. 579 (2): 95–132. doi:10.1016/j.gene.2015.12.061. PMC 4756657. PMID 26772908.

[6] Bourque CW (Jul 2008). "Central mechanisms of osmosensation and systemic osmoregulation". Nature Reviews. Neuroscience. 9 (7): 519–31. doi:10.1038/nrn2400. PMID 18509340. S2CID 205504313.

[2015-Rossier-7] Rossier BC, Baker ME, Studer RA (Jan 2015). "Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited". Physiological Reviews. 95 (1): 297–340. doi:10.1152/physrev.00011.2014. PMID 25540145.

[1998-Ludwig-8] Ludwig M, Bolkenius U, Wickert L, Marynen P, Bidlingmaier F (May 1998). "Structural organisation of the gene encoding the alpha-subunit of the human amiloride-sensitive epithelial sodium channel". Human Genetics. 102 (5): 576–81. doi:10.1007/s004390050743. PMID 9654208. S2CID 22547152.

[9] Thomas CP, Doggett NA, Fisher R, Stokes JB (Oct 1996). "Genomic organization and the 5' flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel". Journal of Biological Chemistry. 271 (42): 26062–6. doi:10.1074/jbc.271.42.26062. PMID 8824247.

[10] Thomas CP, Auerbach SD, Zhang C, Stokes JB (Mar 1999). "The structure of the rat amiloride-sensitive epithelial sodium channel gamma subunit gene and functional analysis of its promoter". Gene. 228 (1–2): 111–22. doi:10.1016/s0378-1119(99)00016-5. PMID 10072764.

[1998-Saxena-11] Saxena A, Hanukoglu I, Strautnieks SS, Thompson RJ, Gardiner RM, Hanukoglu A (Nov 1998). "Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit". Biochemical and Biophysical Research Communications. 252 (1): 208–213. doi:10.1006/bbrc.1998.9625. PMID 9813171.

[12] Canessa CM, Merillat AM, Rossier BC (Dec 1994). "Membrane topology of the epithelial sodium channel in intact cells". The American Journal of Physiology. 267 (6 Pt 1): C1682–90. doi:10.1152/ajpcell.1994.267.6.C1682. PMID 7810611.

[13] Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP (1995). "Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome". Nat. Genet. 11 (1): 76–82. doi:10.1038/ng0995-76. PMID 7550319. S2CID 22106822.

[14] Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW (1994). "Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel". Cell. 79 (3): 407–14. doi:10.1016/0092-8674(94)90250-X. PMID 7954808. S2CID 54282654.

[15] Hansson JH, Schild L, Lu Y, Wilson TA, Gautschi I, Shimkets R, Nelson-Williams C, Rossier BC, Lifton RP (1996). "A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11495–9. doi:10.1073/pnas.92.25.11495. PMC 40428. PMID 8524790.

[16] Inoue J, Iwaoka T, Tokunaga H, Takamune K, Naomi S, Araki M, Takahama K, Yamaguchi K, Tomita K (1998). "A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel". J. Clin. Endocrinol. Metab. 83 (6): 2210–3. doi:10.1210/jcem.83.6.5030. PMID 9626162.

[17] Persu A, Barbry P, Bassilana F, Houot AM, Mengual R, Lazdunski M, Corvol P, Jeunemaitre X (1998). "Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension". Hypertension. 32 (1): 129–37. doi:10.1161/01.hyp.32.1.129. PMID 9674649.

[18] Uehara Y, Sasaguri M, Kinoshita A, Tsuji E, Kiyose H, Taniguchi H, Noda K, Ideishi M, Inoue J, Tomita K, Arakawa K (1998). "Genetic analysis of the epithelial sodium channel in Liddle's syndrome". J. Hypertens. 16 (8): 1131–5. doi:10.1097/00004872-199816080-00008. PMID 9794716. S2CID 31393115.

[19] Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ (1996). "Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel". Cell. 83 (6): 969–78. doi:10.1016/0092-8674(95)90212-0. PMID 8521520. S2CID 970556.

[20] Tamura H, Schild L, Enomoto N, Matsui N, Marumo F, Rossier BC (1996). "Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene". J. Clin. Invest. 97 (7): 1780–4. doi:10.1172/JCI118606. PMC 507244. PMID 8601645.

[21] Firsov D, Schild L, Gautschi I, Mérillat AM, Schneeberger E, Rossier BC (1997). "Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15370–5. doi:10.1073/pnas.93.26.15370. PMC 26411. PMID 8986818.

[22] Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.

[pmid10642508-23] Farr TJ, Coddington-Lawson SJ, Snyder PM, McDonald FJ (February 2000). "Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits". Biochem. J. 345 (3): 503–9. doi:10.1042/0264-6021:3450503. PMC 1220784. PMID 10642508.

[pmid12167593-24] McDonald FJ, Western AH, McNeil JD, Thomas BC, Olson DR, Snyder PM (September 2002). "Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel". Am. J. Physiol. Renal Physiol. 283 (3): F431–6. doi:10.1152/ajprenal.00080.2002. PMID 12167593.

[pmid11244092-25] Harvey KF, Dinudom A, Cook DI, Kumar S (March 2001). "The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel". J. Biol. Chem. 276 (11): 8597–601. doi:10.1074/jbc.C000906200. PMID 11244092.

[pmid14996668-26] Berdiev BK, Jovov B, Tucker WC, Naren AP, Fuller CM, Chapman ER, Benos DJ (June 2004). "ENaC subunit-subunit interactions and inhibition by syntaxin 1A". Am. J. Physiol. Renal Physiol. 286 (6): F1100–6. doi:10.1152/ajprenal.00344.2003. PMID 14996668. S2CID 18384316.

[pmid18632802-27] Boulkroun S, Ruffieux-Daidié D, Vitagliano JJ, Poirot O, Charles RP, Lagnaz D, Firsov D, Kellenberger S, Staub O (October 2008). "Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3". Am. J. Physiol. Renal Physiol. 295 (4): F889–900. doi:10.1152/ajprenal.00001.2008. PMID 18632802.

[pmid18322022-28] Raikwar NS, Thomas CP (May 2008). "Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel". Am. J. Physiol. Renal Physiol. 294 (5): F1157–65. doi:10.1152/ajprenal.00339.2007. PMC 2424110. PMID 18322022.

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[27]

[28]