ZNF133

ZNF133
Identifikatori
Aliasi	ZNF133
Vanjski ID-jevi	OMIM: 604075 HomoloGene: 48184 GeneCards: ZNF133
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	18,316,996 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• intracellular anatomical structure; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	7692
	n/a
	ENSG00000125846
	n/a
	P52736; Q5JXW1
	n/a
NM_001083330; NM_001282995; NM_001282996; NM_001282997; NM_001282998;
	NM_001282999; NM_001283000; NM_001283001; NM_001283002; NM_001283003; NM_001283004; NM_001283005; NM_001283006; NM_001283007; NM_001283008; NM_003434; NM_001352450; NM_001352451; NM_001352452; NM_001352453; NM_001352454; NM_001352455; NM_001352456; NM_001352457; NM_001352458; NM_001352459; NM_001352460; NM_001352461; NM_001352462; NM_001352463; NM_001352464
	n/a
NP_001076799; NP_001269924; NP_001269925; NP_001269926; NP_001269927;
	NP_001269928; NP_001269929; NP_001269930; NP_001269931; NP_001269932; NP_001269933; NP_001269934; NP_001269935; NP_001269936; NP_001269937; NP_003425; NP_001339379; NP_001339380; NP_001339381; NP_001339382; NP_001339383; NP_001339384; NP_001339385; NP_001339386; NP_001339387; NP_001339388; NP_001339389; NP_001339390; NP_001339391; NP_001339392; NP_001339393
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Protein 133 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF133.^[3]^[4]^[5]

Opis

Smatra se da transkripcijski regulatorni proteini koji sadrže tandemno ponovljene domena cinkovih prstiju učestvuju u normalnoj i abnormalnoj ćelijskoj proliferaciji i diferencijaciji. Jedna bogataa klasa takvih transkripcijskih regulatora nalikuje proizvodu segmentacije Drosophila Kruppel, zbog prisustva ponovljenih Cys2-His2 (C2H2) domena cinkovih prstiju, koji su povezani konzerviranim sekvencama, zvanim H / C veze.

Skriningom biblioteke cDNK ljudskog insulina degeneriranim oligonukleotidom koji odgovara sekvenci H/C povezivača, Tommerup et al. (1993) izolirali su cDNK koje potencijalno kodiraju proteine cinkovih prstiju. Tommerup i Vissing (1995) izvršili su analizu sekvenci na nekoliko ovih cDNK i identificirali nekoliko novih gena proteina cinkovog prsta, uključujući ZNF133. Pronašli su dva oblika ZNF133 cDNK, koji predstavljaju različito prerađene transkripte; jedan predviđa protein cinkovog prsta tipa 654 od aminokiselina (PDB U09366) koji sadrži N-terminalni KRAB domen. Vissing et al. (1995) izvijestili su da izvedeni protein ZNF133 sadrži 13 domena cinkovog prsta kojima prethodi navodni degenerirani domen prstiju, te i KRAB A i B boks. Northern blot analizom otkrivena je ekspresija ZNF133 u svim ispitivanim tkivima.

Margolin et al, (1994) pokazali su da KRAB domen ZNF133 funkcionira kao snažan represivni domen transkripcije kada je stopljen sa domenom vezanja DNK kvasca GAL4.^[6]^[7]^[8]^[9]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125846 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tommerup N, Vissing H (Nov 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
^ Vissing H, Meyer WK, Aagaard L, Tommerup N, Thiesen HJ (Sep 1995). "Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins". FEBS Lett. 369 (2–3): 153–7. doi:10.1016/0014-5793(95)00728-R. PMID 7649249.
^ "Entrez Gene: ZNF133 zinc finger protein 133".
^ Margolin, J. F., Friedman, J. R., Meyer, W. K., Vissing, H., Thiesen, H.-J., Rauscher, F. J., III. Kruppel-associated boxes are potent transcriptional repression domains. Proc. Nat. Acad. Sci. 91: 4509-4513, 1994. [PubMed: 8183939]
^ Tommerup, N., Aagaard, L., Lund, C. L., Boel, E., Baxendale, S., Bates, G. P., Lehrach, H., Vissing, H. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. Hum. Molec. Genet. 2: 1571-1575, 1993. [PubMed: 8268908]
^ Tommerup, N., Vissing, H. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 27: 259-264, 1995. [PubMed: 7557990]
^ Vissing, H., Meyer, W. K.-H., Aagaard, L., Tommerup, N., Thiesen, H.-J. Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. FEBS Lett. 369: 153-157, 1995. [PubMed: 7649249]