Oldham had ended the regular season as the league leaders.
Wigan won their second ever Championship this season when they defeated Oldham 13–2 in the play-off final.
The 1921–22 Kangaroo tour of Great Britain also took place during the season, with many of the clubs playing games against the visiting Australasian team.
The 1921–22 Challenge Cup was won by Rochdale Hornets who defeated Hull F.C. 10–9 in the final at Headingley, Leeds on Saturday 6 May 1922, in front of a crowd of 32,596. This was Rochdale's first Challenge Cup Final win in their first, and as of 2017 their only, Challenge Cup Final appearance.[3][4][5]