The 2020–21 season was the 98th season in the existence of Vitória S.C. and the club's 14th consecutive season in the top-flight of Portuguese football. In addition to the domestic league, Vitória de Guimarães participated in this season's editions of the Taça de Portugal and the Taça da Liga. The season covers the period from 26 July 2020 to 30 June 2021.
^ abBraga qualified for the Europa League group stage by winning the 2020–21 Taça de Portugal. Since they would have qualified for the Europa Conference League third qualifying round by finishing fourth, the berth was awarded to the fifth-placed team (Paços de Ferreira), and the Europa Conference League second qualifying round berth reserved to the fifth-placed team was awarded to the sixth-placed team (Santa Clara).
^ abVitória de Guimarães are ranked ahead of Moreirense on head-to-head points: Vitória de Guimarães 4, Moreirense 1.
^Famalicão are ranked ahead of Belenenses SAD on head-to-head points: Famalicão 4, Belenenses SAD 1.