28 February – At least 17 people are killed after two buses collide in San Juan de Opoa, Copán.[3]
March
8 March – Juan Orlando Hernández is found guilty of drug trafficking charges in a federal court in New York City.[4]
June
15 June – President Xiomara Castro announces new measures to reduce gang activity, including building a 20,000-capacity "megaprison" and plans to designate gang members as terrorists.[5]
26 June – Former President Juan Orlando Hernández is sentenced to 45 years in prison and fined $8 million for drug trafficking and firearms offences by a U.S. federal court.[6]
21 August – Honduras reports five suspected cases of the new mpoxclade.[8]
28 August – Honduras announces that it would end its extradition treaty with the United States that had been in place since 1912 following criticism by US ambassador Laura Dogu of a meeting between Honduran and Venezuelan officials.[9]
September
14 September – Juan Lopez, an environmental activist who protested against open-pit iron ore mining in a forest reserve, is shot dead in Tocoa, Colón.[10]
19 September – Two inmates are killed while three others are injured in an attempted jailbreak at a men's prison in Támara.[11]