AP2A2
Protein-coding gene in the species Homo sapiens
AP2A2 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B9K , 1KY6 , 1KY7 , 1KYD , 1KYF , 1KYU , 1QTP , 1QTS , 1W80 , 2JKR , 2JKT , 2VJ0 , 3HS8
Identifiers Aliases AP2A2 External IDs OMIM : 607242 ; MGI : 101920 ; HomoloGene : 5335 ; GeneCards : AP2A2 ; OMA :AP2A2 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in right hemisphere of cerebellum spleen superior frontal gyrus sural nerve right frontal lobe subcutaneous adipose tissue prefrontal cortex canal of the cervix Pituitary Gland ganglionic eminence
Top expressed in perirhinal cortex entorhinal cortex neural layer of retina dentate gyrus of hippocampal formation granule cell stroma of bone marrow CA3 field medullary collecting duct superior frontal gyrus primary visual cortex cerebellar cortex
More reference expression data
BioGPS
Wikidata
AP-2 complex subunit alpha-2 is a protein that in humans is encoded by the AP2A2 gene .[ 5] [ 6] [ 7]
Interactions
AP2A2 has been shown to interact with EPN1 [ 8] SHC1 .[ 9]
References
^ a b c ENSG00000280759, ENSG00000183020 GRCh38: Ensembl release 89: ENSG00000281385, ENSG00000280759, ENSG00000183020 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002957 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Faber PW, Barnes GT, Srinidhi J, Chen J, Gusella JF, MacDonald ME (Sep 1998). "Huntingtin interacts with a family of WW domain proteins" . Human Molecular Genetics . 7 (9): 1463–74. doi :10.1093/hmg/7.9.1463 PMID 9700202 . ^ Robinson MS (Mar 1989). "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)" . The Journal of Cell Biology . 108 (3): 833–42. doi :10.1083/jcb.108.3.833 . PMC 2115374 PMID 2564002 . ^ "Entrez Gene: AP2A2 adaptor-related protein complex 2, alpha 2 subunit" .^ Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature . 394 (6695): 793–7. Bibcode :1998Natur.394..793C . doi :10.1038/29555 . PMID 9723620 . S2CID 4430975 . ^ Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins" . The Journal of Biological Chemistry . 271 (9): 5265–9. doi :10.1074/jbc.271.9.5265 PMID 8617812 .
Further reading
Kirchhausen T (2000). "Clathrin". Annual Review of Biochemistry . 69 : 699–727. doi :10.1146/annurev.biochem.69.1.699 . PMID 10966473 . Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research . 9 (3): 99–106. CiteSeerX 10.1.1.500.923 doi :10.1093/dnares/9.3.99 . PMID 12168954 . Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . David C, McPherson PS, Mundigl O, de Camilli P (Jan 1996). "A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals" . Proceedings of the National Academy of Sciences of the United States of America . 93 (1): 331–5. Bibcode :1996PNAS...93..331D . doi :10.1073/pnas.93.1.331 PMC 40232 PMID 8552632 . Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M (Mar 1996). "Interaction of Shc with adaptor protein adaptins" . The Journal of Biological Chemistry . 271 (9): 5265–9. doi :10.1074/jbc.271.9.5265 PMID 8617812 . Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N (May 1996). "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein" . The Journal of Biological Chemistry . 271 (20): 12111–6. doi :10.1074/jbc.271.20.12111 PMID 8662627 . van Delft S, Schumacher C, Hage W, Verkleij AJ, van Bergen en Henegouwen PM (Feb 1997). "Association and colocalization of Eps15 with adaptor protein-2 and clathrin" . The Journal of Cell Biology . 136 (4): 811–21. doi :10.1083/jcb.136.4.811 . PMC 2132490 PMID 9049247 . Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS (Jun 1997). "Identification and characterization of a nerve terminal-enriched amphiphysin isoform" . The Journal of Biological Chemistry . 272 (26): 16700–6. doi :10.1074/jbc.272.26.16700 PMID 9195986 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, Di Fiore PP, De Camilli P (Aug 1998). "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature . 394 (6695): 793–7. Bibcode :1998Natur.394..793C . doi :10.1038/29555 . PMID 9723620 . S2CID 4430975 . Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins" . Journal of Virology . 73 (2): 1350–61. doi :10.1128/JVI.73.2.1350-1361.1999 . PMC 103959 PMID 9882340 . Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 5 (6): 355–64. doi :10.1093/dnares/5.6.355 PMID 10048485 . Traub LM, Downs MA, Westrich JL, Fremont DH (Aug 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly" . Proceedings of the National Academy of Sciences of the United States of America . 96 (16): 8907–12. Bibcode :1999PNAS...96.8907T . doi :10.1073/pnas.96.16.8907 PMC 17706 PMID 10430869 . Page LJ, Sowerby PJ, Lui WW, Robinson MS (Sep 1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin" . The Journal of Cell Biology . 146 (5): 993–1004. doi :10.1083/jcb.146.5.993 . PMC 2169493 PMID 10477754 . Kim ST, Lim DS, Canman CE, Kastan MB (Dec 1999). "Substrate specificities and identification of putative substrates of ATM kinase family members" . The Journal of Biological Chemistry . 274 (53): 37538–43. doi :10.1074/jbc.274.53.37538 PMID 10608806 . Slepnev VI, Ochoa GC, Butler MH, De Camilli P (Jun 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites" . The Journal of Biological Chemistry . 275 (23): 17583–9. doi :10.1074/jbc.M910430199 PMID 10748223 . Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH (Aug 2000). "RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis" (PDF) . Journal of Cell Science . 113 (16): 2837–44. doi :10.1242/jcs.113.16.2837 . PMID 10910768 .
External links
PDB gallery
1b9k : ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM CLATHRIN ADAPTOR AP2
1gw5 :
1ky6 : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE
1ky7 : THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH AMPHIPHYSIN FXDXF
1kyd : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPSIN DPW PEPTIDE
1kyf : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE
1kyu : AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE IN COMPLEX WITH EPS15 DPF PEPTIDE
1qtp : CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE
1qts : CRYSTAL STRUCTURE OF THE AP-2 CLATHRIN ADAPTOR ALPHA-APPENDAGE
1w80 : CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, BOUND TO 2 PEPTIDES FROM SYNAPTOJANIN170
