Scott served as a delegate during Mississippi's Constitutional Convention of 1817, before serving in the state senate in 1822 and 1826–1827. In 1828, Scott was sworn in as Lieutenant Governor of Mississippi, and in 1832, he was sworn in as the seventh Governor of Mississippi, having defeated Hiram Runnels in the general election of August 1831.
During Scott's administration, the State of South Carolina attempted to nullify a tariff passed by the United States Congress, leading to the Nullification Crisis, in which South Carolina's government threatened to secede from the United States. Like other southern states, Mississippi did not support South Carolina's actions, defusing the crisis.[2]
In 1832, Mississippi ratified a new constitution, which led to a special election for public officials under the new constitution in May 1833. Scott was defeated by Hiram Runnels in this election, but due to disputes over the legality of the special election, Scott was permitted to remain in office. He served until he died on June 12, 1833, due to a cholera epidemic in Jackson, and was succeeded by Charles Lynch.[2]