Adele Fielding

Adele Kay Fielding
Adele Kay Fielding
Alma mater	University of London ; University College London
	Scientific career
Institutions	Mayo Clinic ; Royal Free Hospital ; University College London Hospitals NHS Foundation Trust ; University College London ; University of York ; Hull York Medical School
Thesis	Targeting fusogenic retroviral glycoproteins by ligand display. (1999)

Adele Kay Fielding is a British physician-scientist who is a Professor of Haematology at University College London. Fielding was President of the British Society for Haematology from 2020 until 2022.^[1]

Early life and education

Fielding was a medical student at University College London.^[2] She was a trainee in haematology (the medical specialty covering blood disorders including cancer) and general medicine in London. She moved to the Medical Research Council laboratory in Cambridge for her doctoral research, and completed her doctorate in 1999.^[3]^[4]

Research and career

In 1999, Fielding was appointed assistant professor at the Mayo Clinic.^[4] She returned to the United Kingdom in 2003, where she joined University College London, becoming Professor of Haematology, and the Royal Free Hospital for clinical practice. She moved clinical practice to University College London Hospitals NHS Foundation Trust in 2015, where she worked in the leukemia service. In 2023, she moved to the University of York, where she is a Professor of Haematology and Head of Experimental Biomedicine at the Hull York Medical School.^[5] She is also the Clinical Director of the University of York Centre for Blood Research.^[6] She currently sees patients at the Queens Centre, Castle Hill Hospital, Hull.^[7]

Her research efforts look to improve the lives of people with acute lymphoblastic leukemia (ALL).^[8] She is part of several clinical trials into ALL, which include studying the underlying mechanisms and searching for new treatments.^[9] Fielding has developed an attenuated oncolytic measles virus that can be used as a treatment of ALL.^[2]

Fielding was elected President of the British Society for Haematology in 2020 and was succeeded in 2022 by Josh Wright.^[10]

Selected publications

Hagop Kantarjian; Anthony Stein; Adele K Fielding; et al. (1 March 2017). "Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia". The New England Journal of Medicine. 376 (9): 836–847. doi:10.1056/NEJMOA1609783. ISSN 0028-4793. PMC 5881572. PMID 28249141. Wikidata Q40312849.
Adele K Fielding; Susan M Richards; Rajesh Chopra; et al. (10 October 2006). "Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study". Blood. 109 (3): 944–950. doi:10.1182/BLOOD-2006-05-018192. ISSN 0006-4971. PMID 17032921. Wikidata Q43889424.
Max S Topp; Nicola Gökbuget; Anthony S Stein; et al. (16 December 2014). "Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study". Lancet Oncology Commission. 16 (1): 57–66. doi:10.1016/S1470-2045(14)71170-2. ISSN 1470-2045. PMID 25524800. Wikidata Q34042800.
Burt R, Dey A, Aref S, Aguiar M, Akarca A, Bailey K, Day W, Hooper S, Kirkwood A, Kirschner K, Lee SW, Lo Celso C, Manji J, Mansour MR, Marafioti T, Mitchell RJ, Muirhead RC, Cheuk Yan Ng K, Pospori C, Puccio I, Zuborne-Alapi K, Sahai E, Fielding AK. Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress. Blood. 2019 Oct 24;134(17):1415-1429. doi: 10.1182/blood.2019001398. PMID 31501154; PMCID: PMC6856969.^[11]
^[12] Marks DI, Kirkwood AA, Rowntree CJ, Aguiar M, Bailey KE, Beaton B, Cahalin P, Castleton AZ, Clifton-Hadley L, Copland M, Goldstone AH, Kelly R, Lawrie E, Lee S, McMillan AK, McMullin MF, Menne TF, Mitchell RJ, Moorman AV, Patel B, Patrick P, Smith P, Taussig D, Yallop D, Alapi KZ, Fielding AK. Addition of four doses of rituximab to standard induction chemotherapy in adult patients with precursor B-cell acute lymphoblastic leukaemia (UKALL14): a phase 3, multicentre, randomised controlled trial. Lancet Haematol. 2022 Apr;9(4):e262-e275. doi: 10.1016/S2352-3026(22)00038-2. PMID 35358441; PMCID: PMC8969057.