Born in Rota, Andalusia, Niño began his career with local side UD Roteña, before spending two seasons with professional side Cádiz.[2][3] He returned to Roteña before joining Atlético Sanluqueño in 2019, where he was scouted and signed the following year by La Liga side Atlético Madrid.[4]
He progressed through the academy, forming a prolific partnership with teammate Abde Raihani, with the two scoring 57 goals between them in the 2022–23 season.[5] He featured in the 2022–23 UEFA Youth League for Atlético Madrid, becoming the first player in history to score in every single group stage game, scoring seven in six games.[6][7] In February 2023, he signed a four-year contract renewal with the club.[8] The same month, he trained with the Atlético Madrid first team for the first time.[9]
^Cazón, Patricia (16 February 2023). "Adrián Niño ya se entrena con el Cholo" [Adrián Niño is already training with Cholo]. as.com (in Spanish). Retrieved 12 June 2023.