When hostilities broke out on 18 April, the Army of Thessaly was defeated in successive battles on the border passes, the Battle of Farsala and the Battle of Domokos. By the time of the armistice on 20 May, the Army of Thessaly had been pushed out of Thessaly proper by the Ottoman advance.
As war with the Ottoman Empire increasingly became a possibility in the early autumn of 1912, the bulk of the Hellenic Army was gathered in Thessaly, once again under Crown Prince Constantine, comprising the four peacetime infantry divisions and three newly formed from reservists, a cavalry brigade, and auxiliary units, for a total of some 100,000 men, of which ca. 80,000 effectives.
In the course of the First Balkan War, the Army of Thessaly overcame the fortified Ottoman positions along the border in the Battle of Sarantaporo and advanced north. Despite a setback of a detached division in the Battle of Sorovich, the main army broke through the Ottoman defences at the Battle of Yenidje, forcing, after a few days, the surrender of Thessaloniki and its garrison. Having effected the union with the allied Serbian and Bulgarian armies, the Army of Thessaly was deactivated, with some units going to reinforce the Epirus front and others settling along the new demarcation line in Macedonia.