Upon the designation of the Viceroyalty of the Río de la Plata by the Spanish Empire in 1776, the "Road of the Kingdom of Heaven" leading into Buenos Aires from the east was designated a Camino Real, a "Royal Road" fit for a Viceroy, and afforded improvements and some security. This Royal Road of the West, by 1782, traveled to Mendoza, a city over 600 miles (970 km) to the west (roughly along the modern National Highway 7). Dubbed Federation Road by the paramount Governor Juan Manuel de Rosas in 1836, it was renamed in honor of former President Bernardino Rivadavia in 1857, following the reestablishment of constitutional rule.
The Buenos Aires Metro, inaugurated in 1913, was extended to Rivadavia Avenue in 1926, whereby 11 of the 16 stations on line were built underneath the avenue. Rivadavia was on Buenos Aires' first bus line in 1928, a development that marked the beginning of the end for the city's intricate trolley system. The establishment of the National Highway Bureau in 1932 led to the 1935 designation of the avenue, west of the Federal District, as part of National Highway 7. This change encouraged the rapid development of the suburbs west of Buenos Aires, something which, by 1970, had made the avenue among the most congested in the metro area. A rerouting of Highway 7 north of the avenue began taking shape in the late 1970s and the resulting expressway between Buenos Aires and Luján was completed in 1988. Absent since 1962, a Historic Tramway Line was inaugurated along the Caballito section of Rivadavia Avenue in 1980.