Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), popularly known as baboon syndrome because of its resemblance to the distinctive red buttocks displayed by female baboons, is a systemic dermatitis characterized by well-demarcated patches of erythema distributed symmetrically on the buttocks.[1]
The cause of the syndrome may be drug-related: i.e., induced by systemic administration of hydroxyzine,[2] penicillin,[3] iodinated radio contrast media,[4] and others.
Symptoms and signs
The typical rash commonly appears on buttocks. This then resembles the colour of a baboon's buttocks. Other areas like upper inner thigh and armpits, may be affected by the rash. The rashes are red and well-defined. The presentation is typically symmetrical and not associated with systemic symptoms.[5]
Cause
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Diagnosis
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Treatment
Treatment of symmetrical drug related intertriginous and flexural exanthema involves identifying and stopping the causative agent. Topical steroids can help to reduce the redness.[6]
Epidemiology
Baboon syndrome affects both sexes equally, and can occur at any age, but seems to be more common in childhood than in adulthood.[7]
^Arnold AW, Hausermann P, Bach S, Bircher AJ (2007). "Recurrent flexural exanthema (SDRIFE or baboon syndrome) after administration of two different iodinated radio contrast media". Dermatology. 214 (1): 89–93. doi:10.1159/000096920. PMID17191055. S2CID32523752.
^Utaş S, Ferahbaş A (2009). "Baboon syndrome and segmental vitiligo coexistence". The Turkish Journal of Pediatrics. 51 (4): 392–394. PMID19950853.
^Moreno-Ramírez D, García-Bravo B, Pichardo AR, Rubio FP, Martínez FC (2004). "Baboon syndrome in childhood: easy to avoid, easy to diagnose, but the problem continues". Pediatric Dermatology. 21 (3): 250–253. doi:10.1111/j.0736-8046.2004.21313.x. PMID15165206. S2CID30607230.
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