Brunó Ferenc Straub (5 January 1914 in Nagyvárad, Austria-Hungary (now Oradea, Romania) – 15 February 1996) was a biochemist. As a young scholar he was a research assistant of Albert Szent-Györgyi at the University of Szeged, and subsequently worked at the Molteno Institute, Cambridge, UK. He was the first to obtain actin in a relatively pure state.[1] He founded the Biological Research Centre in Szeged. He was the chairman of the Hungarian Presidential Council from 29 June 1988 to 23 October 1989. He proposed the theory of conformational selection in 1964,[2][3] the same year the Monod–Wyman–Changeux model was proposed.[4][5]
References
- ^ Straub BF (1942). Szent-Györgyi A (ed.). "Actin". Studies from the Institute of Medical Chemistry University Szeged. 1942. II: 3–15.
- ^ Csermely, P.; Palotai, R.; Nussinov, T. (2010). "Induced fit, conformational selection and independent dynamic segments: an extended view of binding events". Trends Biochem. Sci. 35 (10): 539–546. doi:10.1016/j.tibs.2010.04.009. PMC 3018770.
- ^ Orosz, F.; Vértessy, B. G. (2021). "What's in a name? From "fluctuation fit" to "conformational selection": rediscovery of a concept". Hist. Philos. Life Sci. 43: 88. doi:10.1007/s40656-021-00442-2. PMC 8270835.
- ^ Changeux, J.-P. (1964). "Allosteric interactions interpreted in terms of quaternary structure". Brookhaven Symp. Biol. 17: 232–249. PMID 14246265.
- ^ Monod, J; Wyman, J; Changeux, J.-P. (1965). "On the Nature of Allosteric Transitions — a Plausible Model". J. Mol. Biol. 12 (1): 88–118. doi:10.1016/S0022-2836(65)80285-6. PMID 14343300.
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