Share to: share facebook share twitter share wa share telegram print page

CDPPB

CDPPB
Identifiers
  • 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
CompTox Dashboard (EPA)
ECHA InfoCard100.222.673 Edit this at Wikidata
Chemical and physical data
FormulaC23H18N4O
Molar mass366.424 g·mol−1
3D model (JSmol)
  • c3ccccc3-n1nc(-c4ccccc4)cc1NC(=O)c(c2)cccc2C#N
  • InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28) ☒N
  • Key:BKUIZWILNWHFHD-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

CDPPB is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.[1][2][3] It has antipsychotic effects in animal models,[4] and mGluR5 modulators are under investigation as potential drugs for the treatment of schizophrenia,[5] as well as other applications.[6][7]

References

  1. ^ Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR (November 2004). "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo". Journal of Medicinal Chemistry. 47 (24): 5825–8. doi:10.1021/jm049400d. PMID 15537338.
  2. ^ de Paulis T, Hemstapat K, Chen Y, Zhang Y, Saleh S, Alagille D, Baldwin RM, Tamagnan GD, Conn PJ (June 2006). "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes". Journal of Medicinal Chemistry. 49 (11): 3332–44. doi:10.1021/jm051252j. PMID 16722652.
  3. ^ Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP, Conn PJ (May 2007). "Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses". Molecular Pharmacology. 71 (5): 1389–98. doi:10.1124/mol.106.032425. PMID 17303702. S2CID 7004830.
  4. ^ Kinney GG, O'Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK, Chen TB, Wisnoski DD, Lindsley CW, Tiller PR, Smith S, Jacobson MA, Sur C, Duggan ME, Pettibone DJ, Conn PJ, Williams DL (April 2005). "A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models". The Journal of Pharmacology and Experimental Therapeutics. 313 (1): 199–206. doi:10.1124/jpet.104.079244. PMID 15608073. S2CID 14946765.
  5. ^ Lindsley CW, Shipe WD, Wolkenberg SE, Theberge CR, Williams DL, Sur C, Kinney GG (2006). "Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia". Current Topics in Medicinal Chemistry. 6 (8): 771–85. doi:10.2174/156802606777057599. PMID 16719816.
  6. ^ Lecourtier L, Homayoun H, Tamagnan G, Moghaddam B (October 2007). "Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex". Biological Psychiatry. 62 (7): 739–46. doi:10.1016/j.biopsych.2006.12.003. PMC 2910402. PMID 17511968.
  7. ^ Gass JT, Olive MF (April 2009). "Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory". Biological Psychiatry. 65 (8): 717–20. doi:10.1016/j.biopsych.2008.11.001. PMC 2870714. PMID 19100966.


Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.

Read other articles:

قائمة آثار محافظة عجلون

يفتقر محتوى هذه المقالة إلى الاستشهاد بمصادر. فضلاً، ساهم في تطوير هذه المقالة من خلال إضافة مصادر موثوق بها. أي معلومات غير موثقة يمكن التشكيك بها وإزالتها. (ديسمبر 2018) محافظة عجلون. تتناول هذه القائمة المواقع الأثرية المسجَّلة رسمياً لدى دائرة الآثار العامة التابعة لوزار...

 

Bahnhof Štrba

ŠtrbaŠtrba OŽ Talstation der Zahnradbahn im ObergeschossTalstation der Zahnradbahn im Obergeschoss Daten Betriebsstellenart Bahnhof Lage im Netz Anschlussbahnhof Bauform Durchgangsbahnhof Bahnsteiggleise 6 Abkürzung XYSB (DB AG) Preisklasse 2 Lage Stadt/Gemeinde Štrba Ort/Ortsteil Tatranská Štrba Landschaftsverband Prešovský Staat Slowakei Koordinaten 49° 5′ 2″ N, 20° 3′ 56″ O49.08379620.065486Koordinaten: 49° 5′ 2″ N, 20°&...

 

هورلتون

هورلتون الإحداثيات 39°29′51″N 121°23′15″W / 39.4975°N 121.3875°W / 39.4975; -121.3875  تقسيم إداري  البلد الولايات المتحدة[1]  التقسيم الأعلى مقاطعة بوت  خصائص جغرافية ارتفاع 1598 قدم  معلومات أخرى منطقة زمنية زمن منطقة المحيط الهادئ  رمز جيونيمز 5358762  تعديل مصدري...

Kabupaten Jepara

Kabupaten JeparaKabupatenTranskripsi bahasa daerah • HanacarakaꦗꦼꦥꦫDari kiri ke kanan, atas ke bawah: Tanjung Gelam Karimunjawa, Kura-Kura Ocean Park, Monumen Jepara, dan Masjid Agung Baitul Makmur Jepara. LambangJulukan: Kota UkirBumi KartiniScheveningen van JavaThe World Woodcarving CentreMotto: Trus karya tataning bumi(Jawa) Terus bekerja keras membangun daerah(1549 Masehi)[1]PetaKabupaten JeparaPetaTampilkan peta JawaKabupaten JeparaKabupaten Jep...

 

Пам'ятник воїнам-односельчанам (Вербень)

Пам’ятник воїнам-односельчанам Тип пам'ятникКраїна  Україна : ISO3166-1 alpha-3:UKR; ISO3166-1 цифровий:804; Розташування село Вербень Дубенського району Рівненської областіСкульптор О. ЛебедєвМатеріал бетон, цегла, цементВисота 5 м  Пам'ятник воїнам-односельчанам у Вік

 

Dušan Petrović

Serbian politician Dušan PetrovićДушан ПетровићMinister of Agriculture, Trade, Forestry and Water ManagementIn office14 March 2011 – 27 July 2012Preceded bySlobodan Milosavljević (Trade and Services)Saša Dragin (Agriculture, Forestry and Water Management)Succeeded byGoran Knežević (Agriculture, Forestry and Water Management)Rasim Ljajić (Trade)Minister of JusticeIn office15 May 2007 – 7 July 2008Preceded byZoran StojkovićSucceeded bySnežana Malović...

Daftar keuskupan di Benin

Daftar keuskupan di Benin adalah sebuah daftar yang memuat dan menjabarkan pembagian terhadap wilayah administratif Gereja Katolik Roma yang dipimpin oleh seorang uskup ataupun ordinaris di Benin. Konferensi para uskup Benin bergabung dalam Konferensi Waligereja Benin. Per Juni 2020, terdapat 10 buah yurisdiksi, di mana 2 merupakan keuskupan agung dan 8 lainnya merupakan keuskupan sufragan. Daftar keuskupan Provinsi Gerejawi Cotonou Keuskupan Agung Cotonou: Roger Houngbédji, O.P. Keuskupan A...

 

Heinrich von Brühl

Polish-Saxon statesman (1700–1763) This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to remove these template messages) This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Heinrich von Brühl – news · newspapers · books · scholar · JSTOR (May...

 

Чульпа

Чульпа в Сільюстані Чульпа (Chullpa) — циліндрична або прямокутна поховальна вежа, зроблена з каменю або сирцевої цегли. Була поширена у гірських народів Анд, починаючи з останнього періоду існування цивілізації Тіауанако. Найбільшого удосконалення чульпа досягла у дер�...

Иоганн Филипп Саксен-Альтенбургский

В Википедии есть статьи о других людях с именем Иоганн. Иоганн Филипп Саксен-Альтенбургскийнем. Johann Philipp von Sachsen-Altenburg 1-й герцог Саксен-Альтенбургский 1603 — 1639 Регенты Кристиан II (1603 — 23.6.1611),Иоганн Георг I (23.6.1611 — 1618) Совместно с Иоганн Вильгельм,Фридри�...

 

Mokama Assembly constituency

Legislative assembly in India Mokama Assembly constituencyConstituency No. 178 for the Bihar Legislative AssemblyConstituency detailsCountryIndiaRegionEast IndiaStateBiharDistrictPatnaLS constituencyMungerEstablished1952ReservationNoneMember of Legislative Assembly17th Bihar Legislative AssemblyIncumbent Nilam Devi PartyRJDAllianceMahagathbandhanElected year2022 Mokama Assembly constituency is one of 243 constituencies of legislative assembly of Bihar.[1] It is a part of Munger Lok Sa...

 

Misty (TV series)

2018 South Korean TV series MistyPromotional posterHangul미스티Revised RomanizationMiseutiMcCune–ReischauerMisŭt'i GenreMelodramaMysteryThrillerRomanceCreated byJTBCPlot LineWritten byJae In (Jane Jae-in Kim)[1]Directed byMo Wan-ilCreative directorsYoo Jae-kyoo (Lighting)Won Ji-hwan (Art)Jang Han-seung (Martial arts)Gaemi (Music)Kang Eun-kyung (Script)[2]StarringKim Nam-jooJi Jin-heeComposerGo Sung-pil's Music Score (고성필스코어뮤직)[2]Country of originS...

Collinsville City Hall and Fire Station

United States historic placeCollinsville City Hall and Fire StationU.S. National Register of Historic Places Fire station section, with the city hall to far leftShow map of IllinoisShow map of the United StatesLocation125 S. Center St., Collinsville, IllinoisCoordinates38°40′16″N 89°59′11″W / 38.67111°N 89.98639°W / 38.67111; -89.98639Arealess than one acreBuilt1885 (1885), 1910Architectural styleItalianate, Romanesque RevivalNRHP reference&#...

 

Alberta Investment Management Corporation

Sovereign wealth fund of Alberta, Canada This article may contain an excessive amount of intricate detail that may interest only a particular audience. Please help by spinning off or relocating any relevant information, and removing excessive detail that may be against Wikipedia's inclusion policy. (February 2017) (Learn how and when to remove this template message) Alberta Investment Management CorporationTypeCrown corporationIndustryAsset managementHeadquartersEdmonton, Alberta, CanadaKey p...

 

Grigoriopol transmitter

47°16′54″N 29°25′22″E / 47.28167°N 29.42278°E / 47.28167; 29.42278 The Grigoriopol transmitter, officially the Transnistrian Radio and Television Center, is a very large broadcasting facility situated near Maiac, an urban settlement 11 km (7 miles) northeast of Grigoriopol, Transnistria (Moldova).[1][2][3] History At the end of the 1960s, the Soviet Union began building a powerful radio broadcasting station for propaganda to Wes...

Western Sahara partition agreement

Treaty between Mauritania and Morocco Map showing the partition agreement per the treaty The Western Sahara partition agreement, formally the Convention concerning the State frontier line, was a treaty signed at Rabat on 14 Apr 1976 between Morocco and Mauritania in order to partition the disputed territory of Western Sahara between them following the withdrawal of Spain under the Madrid Accords.[1][2] The treaty was intended to demarcate the borders between Morocco and Maurit...

 

Cape batis

Species of bird Cape batis Male in KwaZulu-Natal, South Africa Female in the Western Cape, South Africa Conservation status Least Concern (IUCN 3.1)[1] Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Chordata Class: Aves Order: Passeriformes Family: Platysteiridae Genus: Batis Species: B. capensis Binomial name Batis capensis(Linnaeus, 1766) Synonyms Muscicapa capensis Linnaeus, 1766 The Cape batis (Batis capensis) is a small, stout insect-eating p...

 

HMY Bezan

The Bezan History England NameHMY Bezan Launched1661 FateBroken up in 1687 General characteristics Class and typeRoyal yacht Tons burthen35 (bm) Length34 ft (10 m) (overall) Beam14 ft (4.3 m) Draught3 ft 6 in (1.07 m) Armament4 guns A Royal Visit to the Fleet in the Thames Estuary, 1672. On the extreme right is the forepart of a bezan yacht, thought to be the one given to Charles II in 1661 HMY Bezan (or Bezaan) was a Royal Yacht of the Royal Navy of England...

DJ Amadeus

Ukrainian-born DJ and music producer A major contributor to this article appears to have a close connection with its subject. It may require cleanup to comply with Wikipedia's content policies, particularly neutral point of view. Please discuss further on the talk page. (February 2014) (Learn how and when to remove this template message) DJ AmadeusBackground informationBirth nameDenys IvanovBornKharkiv, UkraineGenresElectro, HouseOccupation(s)DJ, ProducerLabelsDeeper Records NYC, Flash Traxx,...

 

Soundproof (film)

British TV series or programme SoundproofGenreThrillerWritten bySukey FisherDirected byEdmund CoulthardStarringSusan LynchJoseph MawleJoanna DunbarBrendan CoyleNeil StukeMichael ColganEve MylesComposersMark RichterMax RichterCountry of originUnited KingdomOriginal languagesEnglishBSLNo. of episodes1ProductionExecutive producersRobin GutchHilary SalmonProducerMadonna BaptisteCinematographyPeter GreenhalghEditorWilliam DiverRunning time90 minutesProduction companyBlast! FilmsOriginal relea...

 
Kembali kehalaman sebelumnya