In 2009, Wake signed with the Miami Dolphins and remained with the team until 2019, when he signed with the Tennessee Titans. Throughout his career, Wake has established himself as one of the premier edge rushers in the NFL. He has been selected to five Pro Bowls (four at defensive end, one at outside linebacker), and is a four-time first or second-team All-Pro. His 98 sacks with the Dolphins rank him second all-time in club history to Pro Football Hall of FamerJason Taylor's 131 sacks, and his 100.5 career sacks also rank second all-time as an undrafted free agent behind John Randle's 137.5.
Prior to the 2005 NFL draft, Wake worked out at Penn State's Pro Day and ran a 4.55-second 40-yard dash.[7]
New York Giants
Following his college career, Wake joined the New York Giants in April 2005 but was released in June.[8]
BC Lions
Wake signed a free agent contract with the BC Lions of the Canadian Football League in May 2007. Switching from linebacker to defensive end, a rejuvenated Wake had an immediate impact with the team, and was named the Defensive Player of the Week for the first week of the 2007 CFL season after an impressive debut (7 tackles, 3 quarterback sacks) in a 24–22 Lions' victory over the Toronto Argonauts.[9]
"I wanted to eliminate all the fluff. It wasn't about whoever offered the biggest deal. It was about the coaching staffs, the opportunity, the organizations. Miami put themselves above the others in those things."
After receiving interest from 17 total NFL teams and working out for eight, Wake signed with the Dolphins on January 18, 2009.[7] The four-year deal included a $1 million signing bonus and had a potential value of $4.9 million.[7]
Wake started the first game of his NFL career during the 2009 season against the Bills in Week 4 and responded with two sacks, four tackles for a loss, and a forced fumble.[17]
During the 2010 season, Wake had a memorable Week 6 against the Green Bay Packers. He had three sacks, including one on third down in overtime, bringing his total to six sacks in five games, already surpassing his total the previous year of 5½ sacks with limited playing time. He ended a game against the Jets with a sack on quarterback Mark Sanchez completing his second of the game. Wake would lead the NFL in sacks at one point and eventually finish third in the NFL (second in the AFC) in sacks. By the end of the season, Wake had recorded 14 sacks, 57 tackles, and three forced fumbles.[18]
Wake was named a starter for the 2011 AFC Pro Bowl team at outside linebacker.[19] Wake was also named to The Sporting News 2010 All-Pro Team and AP's Second All-Pro team.[20] He was 3rd in the league with 52 quarterback pressures, behind only Chris Long and Julius Peppers. He was ranked 63rd by his fellow players on the NFL Top 100 Players of 2011.[21]
On May 5, 2012, Wake signed a four-year contract extension with the Dolphins reported to be worth a total of $49 million, $20 million of which was guaranteed.[22]
After being moved from outside linebacker to defensive end for the 2012 season, Wake had arguably his best season in the NFL. He totaled 53 tackles and 15 sacks, including 4.5 sacks in one game against the Arizona Cardinals. That season, Wake was named a starter for the Pro Bowl for the second time and, together with Randy Starks, became the first of two Dolphins to make the Pro Bowl at two different positions. He was also named a First-team All-Pro by both the AP and the PFWA for the first time in his career.
Wake earned AFC Defensive Player of the Week honors for his performance against the Cincinnati Bengals in Week 9 of the 2013 season, racking up five tackles, three sacks, two tackles for loss, two quarterback hits and a safety in the Dolphins’ 22–20 overtime victory.[23] Wake sacked Bengals quarterback Andy Dalton in overtime for a safety to end the game, giving the Dolphins a 22–20 victory. It was only the third game in NFL history to end with an overtime safety.[24] He ended the season with 8.5 sacks and another Pro Bowl selection.[25][26]
After an unproductive start to the 2015 season, in which the Dolphins were 1–3 and Wake had one tackle, head coach Joe Philbin was fired and replaced with tight ends coach Dan Campbell. Wake returned to his dominant form, recording six sacks and four forced fumbles in a two-week span, which were both wins against the Titans and Texans. In a game against the Patriots, Wake notched his seventh sack, which put him in second place on the NFL leaderboard, but he was also injured and carried off the field on a later play. On October 30, 2015, NFL Insider Ian Rapoport reported, due to an Achilles injury, that Wake was out for the rest of the 2015 NFL season.[27]
Wake had a bounce-back season in 2016 after the Achilles injury in 2015. On December 17, 2016, Wake got his first career interception by picking off Jets quarterback Bryce Petty. He finished the season with 11.5 sacks, was named to his fifth Pro Bowl and was second-team All-Pro.[28] He was also ranked 62nd on the NFL Top 100 Players of 2017.[29]
On February 18, 2017, Wake signed a two-year contract extension with the Dolphins through the 2018 season, worth up to $18 million.[30][31]
In the 2017 season, Wake started all 16 games, recording 36 combined tackles and 10.5 sacks.[32] He was ranked 74th by his peers on the NFL Top 100 Players of 2018.[33]
In the 2018 season, Wake appeared in and started 14 games. He finished with 6.5 sacks, 36 total tackles, one pass defended, and one forced fumble.[34]
Tennessee Titans
On March 13, 2019, Wake signed a three-year, $23 million contract with the Tennessee Titans.[35]
In the season-opener against the Cleveland Browns, Wake sacked Baker Mayfield 2.5 times, putting him in the 100 sacks club.[36] One of his sacks resulted in a safety and his effort helped lead the Titans to a 43–13 win.[37] He was named AFC Defensive Player of the Week for his performance.[38] On November 26, 2019, Wake was placed on injured reserve.[39] He played in nine games in the 2019 season.[40]
On March 12, 2020, Wake was released by the Titans.[41]