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Chromonychia

Chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues.[1]: 658 

Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia.[2] Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy[3][4]

Also chromonychia is associated with AIDS. A significant association (p<0.05) was found between chromonychia and CD4 counts of below 200 per cubic millimeter.[5]

References

  1. ^ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
  2. ^ Unamuno P, Fernández-López E, Santos C (July 1992). "Leukonychia due to cytostatic agents". Clin. Exp. Dermatol. 17 (4): 273–4. doi:10.1111/j.1365-2230.1992.tb02166.x. PMID 1451320.
  3. ^ Chapman S, Cohen PR (April 1997). "Transverse leukonychia in patients receiving cancer chemotherapy". South. Med. J. 90 (4): 395–8. doi:10.1097/00007611-199704000-00006. PMID 9114829.
  4. ^ Dasanu, Constantin A; Vaillant, JG; Alexandrescu, DT (October 31, 2006). "Distinct patterns of chromonychia, Beau's lines, and melanoderma seen with vincristine, adriamycin, dexamethasone therapy for multiple myeloma". Dermatology Online Journal. 12 (6): 10. PMID 17083890.
  5. ^ Monsel G, Ly F, Canestri A, Diousse P, Ndiaye B, Caumes E (March 2008). "[Prevalence of skin disorders in HIV patients in Senegal and relationship to degree of immunosuppression]". Ann Dermatol Venereol (in French). 135 (3): 187–93. doi:10.1016/j.annder.2007.11.022. PMID 18374849.


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