Share to: share facebook share twitter share wa share telegram print page

Cyclic 3-hydroxymelatonin

Cyclic 3-hydroxymelatonin
Names
IUPAC name
1-[(3aS,8bR)-8b-Hydroxy-7-methoxy-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-3-yl]ethanone
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C13H16N2O3/c1-8(16)15-6-5-13(17)10-7-9(18-2)3-4-11(10)14-12(13)15/h3-4,7,12,14,17H,5-6H2,1-2H3/t12-,13+/m0/s1
    Key: VADOSKJWFKUPQF-QWHCGFSZSA-N
  • CC(=O)N1CC[C@@]2([C@H]1NC3=C2C=C(C=C3)OC)O
Properties
C13H16N2O3
Molar mass 248.282 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Cyclic 3-hydroxymelatonin (3-OHM) is a metabolite of melatonin and an antioxidant more potent than melatonin.[1] It is a non-radical species and does not further propagate the radical chain reaction

It is a footprint product of the reaction between melatonin and hydroxyl radical.[2]

References

  1. ^ Tan, Dun-Xian; Hardeland, R.; Manchester, L. C.; Galano, A.; Reiter, R. J. (May 11, 2014). "Cyclic-3-hydroxymelatonin (C3HOM), a potent antioxidant, scavenges free radicals and suppresses oxidative reactions". Current Medicinal Chemistry. 21 (13): 1557–1565. doi:10.2174/0929867321666131129113146. PMID 24304286 – via PubMed.
  2. ^ Tan, Dun-Xian; Manchester, LucienC.; Reiter, RusselJ.; Plummer, BenjaminF. (March 19, 1999). "Cyclic 3-Hydroxymelatonin: A Melatonin Metabolite Generated as a Result of Hydroxyl Radical Scavenging". Biological Signals and Receptors. 8 (1–2): 70–74. doi:10.1159/000014571 (inactive 1 November 2024). PMID 10085465 – via Silverchair.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)

Read other articles:

Box joint

Type of woodworking joint Not to be confused with Finger joint. Box joint A box joint is a woodworking joint made by cutting a set of complementary, interlocking profiles in two pieces of wood, which are then joined (usually) at right angles, usually glued. The glued box joint has a high glued surface area resulting in a strong bond, on a similar principle to a finger joint. Box joints are used for corners of boxes or box-like constructions, hence the name. The joint does not have the same in...

 

Rita Josefa Pujalte Sánchez

Rita Josefa Pujalte Sánchez Información personalNombre religioso Rita de la Virgen Dolorosa y Rita Dolores del Corazón de Jesús Pujalte Sánchez Nacimiento 18 de febrero de 1853 Aspe (España) Fallecimiento 20 de julio de 1936 (83 años)Canillejas (España) Nacionalidad EspañolaInformación profesionalOcupación Monja Información religiosaFestividad 20 de julio Orden religiosa Hermanas de la Caridad del Sagrado Corazón de Jesús [editar datos en Wikidata] Rita Josefa Pujalte ...

 

Marijo Šivolija

Marijo Šivolija Datos personalesNombre completo Marijo Šivolija-JelicaNacimiento Rijeka, Yugoslavia29 de junio de 1981 (42 años)Carrera deportivaRepresentante de Croacia CroaciaDeporte Boxeo               Medallero Boxeo masculino Evento O P B Campeonato Mundial 0 1 0 Campeonato Europeo 0 1 0 [editar datos en Wikidata] Marijo Šivolija-Jelica (Rijeka, Yugoslavia, 29 de junio de 1981) es un deport...

Bandeira do Camboja

Bandeira do Camboja Aplicação ... Proporção 2:3 Adoção 23 de Setembro de 1993 Tipo Nacional, uso civil, estatal e militar em terra e no mar[1] A bandeira do Camboja foi adotada oficialmente em 23 de setembro de 1993, após o restabelecimento da monarquia no país. A bandeira possui três listras horizontais, tendo a central (de cor vermelha) o dobro da largura das outras duas faixas (de cor azul). No meio da faixa vermelha está representada a entrada do templo de Angkor Wat. Bandeiras ...

 

Zeda Salim

Zeda SalimLahirZurayda Salim11 Mei 1987 (umur 36) Surabaya, Jawa Timur, IndonesiaNama lainZeda SalimPekerjaanNews AnchorHost Infotainment Zeda Salim atau Zurayda Salim (lahir 11 Mei 1987) adalah eks news anchor yang sekarang sudah berganti menjadi host infotaiment asal Indonesia. Acara Tatap Mata (Trans 7) Seputar Indonesia (RCTI) Silet (RCTI) Dua Sisi (RCTI) sebagai presenter Pranala luar Zeda Salim di Twitter lbsPembawa acara berita RCTISaat ini Rizky Hasan Ledi Marina Ryanka Putr...

 

إدارة الغذاء والدواء (الولايات المتحدة)

  إدارة الغذاء والدواء (الولايات المتحدة) (بالإنجليزية: Food and Drug Administration)‏  إدارة الغذاء والدواء (الولايات المتحدة)   تفاصيل الوكالة الحكومية البلد الولايات المتحدة  مؤسس هارفي واشنطن ويلي  تأسست 1906[1] المركز الحكومة الفيدرالية للولايات المتحدة الإحداثيات 39...

Kaarthika (TV series)

Indian TV series or programme KaarthikaGenreDramaCreated byEkta KapoorStarringJennifer Winget Abhay Vakil Aditya VaidyaOpening themeIraade... I Have It In MeEnding themeI can do itCountry of originIndiaOriginal languageHindiNo. of seasons1No. of episodes52ProductionExecutive producerEkta KapoorProducersEkta KapoorShobha KapoorRunning time30 minutesProduction companyBalaji TelefilmsOriginal releaseNetworkHungama TVRelease27 September (2004-09-27)[1] –23 December 2004&#...

 

Parnassus

Salah satu lukisan dari galeri Parnassus. Parnassus adalah lukisan lukisan karya seniman Italia pada zaman Renaissance, Raphael di Raphael Rooms (Stanze di Raffaello), di Istana Vatikan, Roma, dicat pada komisi dari Paus Julius II.[1] Dinding kemungkinan adalah dinding kedua setelah Stanza della Segnatura yang dicat, pada sekitar 1511, setelah La Disputa dan sebelum The School of Athens, yang menempati dinding lain ruangan.[1][2] Seluruh ruangan menunjukkan empat bidan...

 

Jembatan Penyeberangan Orang Pinisi Karet Sudirman

Artikel ini terlalu bergantung pada referensi dari sumber primer. Mohon perbaiki artikel ini dengan menambahkan sumber sekunder atau tersier. (Pelajari cara dan kapan saatnya untuk menghapus pesan templat ini) Artikel ini membutuhkan rujukan tambahan agar kualitasnya dapat dipastikan. Mohon bantu kami mengembangkan artikel ini dengan cara menambahkan rujukan ke sumber tepercaya. Pernyataan tak bersumber bisa saja dipertentangkan dan dihapus.Cari sumber: Jembatan Penyeberangan Orang Pinis...

Landkreis Worbis (1945–1952)

Der Landkreis Worbis im Jahr 1948 Der Landkreis Worbis, von seiner Gründung bis ins Jahr 1946 Landkreis Eichsfeld, war ein Landkreis, der von 1945 bis 1952 im Land Thüringen der SBZ bzw. der DDR bestand. Er hatte seinen Sitz in Heiligenstadt. Inhaltsverzeichnis 1 Geschichte 2 Landräte 3 Literatur 4 Weblinks 5 Einzelnachweise Geschichte In einer Verordnung über die Kreiseinteilung des Landes Thüringen vom 8. August 1945 wurden die ehemaligen preußischen Landkreise Worbis und Heiligenstad...

 

Eric Swalwell

American lawyer & politician (born 1980) Eric SwalwellOfficial portrait, 2016Member of the U.S. House of Representativesfrom CaliforniaIncumbentAssumed office January 3, 2013Preceded byPete Stark (redistricting)Constituency15th district (2013–2023)14th district (2023–present)Member of the Dublin City CouncilIn officeDecember 7, 2010 – January 3, 2013Preceded byKate Ann ScholzSucceeded byAbe Gupta Personal detailsBornEric Michael Swalwell (1980-11-16) Novembe...

 

PSV in het seizoen 2016

PSV – seizoen 2016/17 Naam Philips Sport Vereniging Stadion Philips Stadion Capaciteit 35.000 Complex De Herdgang Voorzitter Jan Albers Algemeen directeur Toon Gerbrands Manager Marcel Brands Trainer Phillip Cocu Assistent Ruud Brood Chris van der Weerden (Hoofd)sponsor energiedirect.nl Competitie EredivisieKNVB BekerUEFA Champions League Thuis Uit Champions League (uit) Geldig voor 2016/17 Chronologie ← Vorige Volgende → 2015/16 2017/18 Portaal    Voetbal Het seizoen 2016/17 ...

1-ша аеромобільна дивізія (Україна)

У Вікіпедії є статті про інші значення цього терміна: 1-ша дивізія. Тактична група «Південь»(2003—2004) 1-ша аеромобільна дивізія(1993—2003) Нарукавний знак дивізіїНа службі 1 червня 1993—2003Країна  УкраїнаВид Сухопутні військаТип  Аеромобільні військаЧисельність дивізіяУ...

 

I з'їзд КП(б)У

Перший з'їзд відбувся в Москві за адресою: вул. Рождественка, 11. Тепер це приміщення Московського архітектурного інституту І з'їзд КП(б)У — з'їзд Комуністичної партії (більшовиків) України, що відбувся 5–12 липня 1918 року в Москві. На з'їзді було 65 делегатів з ухвальним г...

 

Iqbal Khan (actor)

Indian actor (born 1981) Iqbal KhanKhan in 2023BornMohammed Iqbal Khan (1981-02-10) 10 February 1981 (age 42)[1]Jammu and Kashmir, IndiaOccupationsModelactorYears active2002–presentSpouse Sneha Chhabra Khan ​(m. 2007)​Children2 Mohammed Iqbal Khan (born 10 February 1981[1]), more commonly known as Iqbal Khan, is an Indian actor. He was a contestant on Fear Factor: Khatron Ke Khiladi 6. Early life Khan was born in Kashmir and began schoo...

Dargin languages

Dialect continuum of Northeast Caucasian languages DarginRegionSouthcentral Dagestan[1]Native speakers490,000 (2010 census)[1]Language familyNortheast Caucasian DarginDialects Dargwa Kajtak Kubachi Itsari Chirag Language codesISO 639-2darISO 639-3darGlottologdarg1242  Dargin The Dargin languages consist of a dialect continuum of Northeast Caucasian languages spoken by the Dargin people in southcentral Dagestan. Kajtak, Kubachi, Itsari, and Chirag are often consi...

 

Music of Final Fantasy VIII

Music from the video game Final Fantasy VIII Music of Final Fantasy Final Fantasy I and II Final Fantasy III Final Fantasy IV Final Fantasy V Final Fantasy VI Final Fantasy VII series Final Fantasy VIII Final Fantasy IX Final Fantasy X Final Fantasy X-2 Final Fantasy XI Final Fantasy XII Final Fantasy XIII Final Fantasy XIII-2 Lightning Returns: Final Fantasy XIII Final Fantasy XIV Final Fantasy XV Final Fantasy XVI Tactics series Chocobo series Crystal Chronicles series Compilation albums Co...

 

List of titles and honours of Prince Philip, Duke of Edinburgh

Prince Philip, Duke of Edinburgh (10 June 1921 – 9 April 2021), received numerous titles, decorations and honorary appointments, both before and during his time as consort to Queen Elizabeth II. Each is listed below. Where two dates are shown, the first indicates the date of receiving the title or award (the title as Prince Philip of Greece and Denmark being given as from his birth) and the second indicates the date of its loss, renunciation or when its use was discontinued. Royal and noble...

The Jewel in the Crown (TV series)

1984 British television series This article is about the 1984 television miniseries. For the 1966 novel on which it was based, see The Jewel in the Crown (novel). For the Fairport Convention album, see Jewel in the Crown (album). The Jewel in the CrownThe Jewel in the Crown opening titlesCreated by Christopher Morahan Jim O'Brien Ken Taylor Irene Shubik Based onThe Raj Quartetby Paul ScottStarring Art Malik Geraldine James Saeed Jaffrey Peggy Ashcroft Charles Dance Tim Pigott-Smith Eric Porte...

 

Doll Master

2004 South Korean filmDoll MasterTheatrical posterDirected byJeong Yong-kiWritten byJeong Yong-giProduced byHan Man-taekCinematographyJo Cheol-hoEdited byNam Na-yeongDistributed byLotte CinemaCineclick AsiaRelease date 30 July 2004 (2004-07-30) Running time90 minutesCountrySouth KoreaLanguageKoreanBudget$2 million The Doll Master (Korean: 인형사; RR: Inhyeongsa) is a 2004 South Korean horror film directed by Jeong Yong-ki. Plot 60 years ago, a doll and ...

 
Kembali kehalaman sebelumnya