DAPK1

DAPK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IG1, 1JKK, 1JKL, 1JKS, 1JKT, 1P4F, 1WVX, 1WVY, 1YR5, 2W4J, 2W4K, 2X0G, 2XUU, 2XZS, 2Y0A, 2Y4P, 2Y4V, 2YAK, 3DFC, 3DGK, 3EH9, 3EHA, 3F5G, 3F5U, 3GU4, 3GU5, 3GU6, 3GU7, 3GU8, 3GUB, 3ZXT, 4B4L, 4PF4, 4TL0, 4TXC, 4UV0, 4YO4, 4YPD, 5AUW, 5AUU, 5AV1, 5AUY, 5AUT, 5AUX, 5AUV, 5AUZ, 5AV0, 5AV4, 5AV2, 5AV3
Identifiers
Aliases	DAPK1, DAPK, death associated protein kinase 1, ROCO3
External IDs	OMIM: 600831; MGI: 1916885; HomoloGene: 3626; GeneCards: DAPK1; OMA:DAPK1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	87,708,634 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	60,911,005 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; palpebral conjunctiva; ; placenta; ; left ovary; ; middle temporal gyrus; ; parietal pleura; ; corpus epididymis; ; gallbladder; ; pancreatic ductal cell; ; monocyte;
	Top expressed in
	saccule; ; lateral septal nucleus; ; otic vesicle; ; left lung lobe; ; olfactory tubercle; ; subiculum; ; genital tubercle; ; piriform cortex; ; pineal gland; ; anterior amygdaloid area;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; GTP binding; syntaxin-1 binding; kinase activity; protein binding; identical protein binding; calmodulin-dependent protein kinase activity; protein serine/threonine kinase activity; calmodulin binding; ATP binding; protein kinase activity;
Cellular component	plasma membrane; actin cytoskeleton; cytoskeleton; cytoplasm; nucleus;
Biological process	regulation of apoptotic process; negative regulation of translation; phosphorylation; negative regulation of apoptotic process; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of autophagy; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; apoptotic signaling pathway; protein autophosphorylation; regulation of translation; extrinsic apoptotic signaling pathway via death domain receptors; signal transduction; apoptotic process; regulation of NMDA receptor activity; protein phosphorylation; positive regulation of autophagy; intracellular signal transduction; cellular response to interferon-gamma; cellular response to hydroperoxide;
	Sources:Amigo / QuickGO
Orthologs
	1612
	69635
	ENSG00000196730
	ENSMUSG00000021559
	P53355
	Q80YE7
	NM_001288729; NM_001288730; NM_001288731; NM_004938
	NM_001285917; NM_029653; NM_134062
	NP_001275658; NP_001275659; NP_001275660; NP_004929
	NP_001272846; NP_083929; NP_598823
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.^[5]

Function

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.^[6]

In melanocytic cells DAPK1 gene expression may be regulated by MITF.^[7]

As a drug target

Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers.^[8] This has not been demonstrated in actual patients.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196730 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021559 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Sep 1995). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics. 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
^ "Entrez Gene: DAPK1 death-associated protein kinase 1".
^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
^ Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH (Jul 2015). "Death-associated protein kinase 1 promotes growth of p53-mutant cancers". The Journal of Clinical Investigation. 125 (7): 2707–20. doi:10.1172/JCI70805. PMC 4563671. PMID 26075823.