DPF2

DPF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IUF
Identifiers
Aliases	DPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDs	OMIM: 601671; MGI: 109529; HomoloGene: 21265; GeneCards: DPF2; OMA:DPF2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,354,262 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,963,038 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; Achilles tendon; ; ventricular zone; ; body of uterus; ; right ovary; ; left ovary; ; ganglionic eminence; ; canal of the cervix; ; muscle layer of sigmoid colon;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural layer of retina; ; ventricular zone; ; otic vesicle; ; internal carotid artery; ; external carotid artery; ; primitive streak; ; epiblast; ; lens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription corepressor activity; histone acetyltransferase activity; histone binding; H3K9me3 modified histone binding; lysine-acetylated histone binding;
Cellular component	nucleus; nucleoplasm; intracellular membrane-bounded organelle; centrosome; cytoplasm; cytosol; histone acetyltransferase complex; nBAF complex;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; apoptotic signaling pathway; apoptotic process; negative regulation of transcription by RNA polymerase II; chromatin organization; nervous system development; histone acetylation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; negative regulation of myeloid progenitor cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	5977
	19708
	ENSG00000133884
	ENSMUSG00000024826
	Q92785
	Q61103
	NM_006268; NM_001330308
	NM_001291078; NM_011262
	NP_001317237; NP_006259; NP_006259.1
	NP_001278007; NP_035392
	Wikidata
View/Edit Human	View/Edit Mouse

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.^[5]^[6]

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133884 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024826 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL, Buchman VL (Feb 2002). "Cerd4, third member of the d4 gene family: expression and organization of genomic locus". Mamm Genome. 12 (11): 862–6. doi:10.1007/s00335-001-3039-1. PMID 11845289. S2CID 2149578.
^ ^a ^b "Entrez Gene: DPF2 D4, zinc and double PHD fingers family 2".