Santiago attended and played Junior College basketball at New Mexico Military Institute in Roswell, New Mexico and played NCAA Division I basketball at the University of New Mexico. He finished up his collegiate career at the NAIA school of Saint Vincent College in Latrobe, Pennsylvania, where he was named NAIA player of the year. In 2019 Daniel Santiago obtained a college degree in General Studies with concentrations in Social Work, Sociology and History from the University of South Florida.[3]
From 2000 to 2001 he played for the NBA's Phoenix Suns as a back-up center until being released.
He returned to the NBA in 2003, playing two seasons with the Milwaukee Bucks.
In September 2012, Santiago signed with Boca Juniors in Argentina.[7] In March 2013, he was selected as the league's best center for the season.[8] In May 2013, he joined the Mets de Guaynabo in Puerto Rico.[9]
Santiago's paternal grandfather, Pedro Santiago Rodríguez, was a well known baseball player in Puerto Rico and emigrated to the United States to play. Due to his small stature he was nicknamed "Jockey", while grandson Daniel received the "El Gigante" (the giant) moniker. Puerto Rico's Jockey Rodríguez retired from baseball with the Albuquerque Dukes team under the name Pedro Santiago.
Santiago was raised in the West Texas area of Lamesa on a cotton farm and later in Albuquerque, New Mexico where his parents, Stan and Diana Santiago, originated. He has two younger brothers, Matthew and Jarrett Santiago.
Santiago's NBA stats in 122 games were: 417 points (3.4 per game), 260 rebounds (2.1 per game), 38 assists (0.3 per game), 39 steals (0.3 per game) and 47 blocks (0.4 per game). He shot a .469 field goal percentage, and a .685 free throw percentage.
