From November 2014 until October 2015 he worked at Baidu. After that, he worked at Google.[7] In 2016, Amodei joined OpenAI.[8]
In 2021, Amodei and his sister Daniela founded Anthropic along with other former senior members of OpenAI. The Amodei siblings were among those who left OpenAI due to directional differences.[9]
In July 2023, Amodei warned a United States Senate judiciary panel of the dangers of AI, including the risks it poses in the development and control of weaponry.[10]
In September 2023, Amodei and his sister Daniela were named as two of the TIME 100 Most Influential People in AI (TIME100 AI).[11]
In November 2023, the board of directors of OpenAI approached Amodei about replacing Sam Altman and potentially merging the two startups. Amodei declined both offers.[12]
In October 2024, Amodei published an essay named "Machines of Loving Grace",[13] in which he lays out a vision for how AI could radically improve human welfare assuming the risks are successfully managed.[14]