In 1996, while working as a consultant for Hewlett Packard Labs, Cliff invented the "ZIP" trading algorithm. In 1998 he resigned his post at MIT to take up a job as a senior research scientist at the HP Labs European Research Centre in Bristol, UK, where he founded and led HP's Complex Adaptive Systems research group.
In 1999, Cliff (who described himself in a 2001 press interview as "a very bad amateur DJ")[15]
invented hpDJ,[8][9] the world's first fully automated DJ system for electronic dance music (EDM), which automatically generated a serial play-order for a set of EDM tracks, and then did automated beat-detection, time-stretching/compression, and phase-alignment to create "seamless" continuous beat-matched mixes from one track into another. In this sense, hpDJ was the precursor to present-day DJ beat-matching mix automation tools such as those found in Traktor. The hpDJ project was the subject of
multiple international patents invented or co-invented by Cliff[16] over 2001–2005, and included patents[17][18] for a wrist-mounted device which monitored the wearer's biosignals such as heart-rate and perspiration, and included movement and location sensors: the intention was that these devices would be worn by members of the hpDJ's audience to provide feedback to hpDJ on how the audience was responding to the music being played.
In early 2005, Cliff moved to Deutsche Bank's Foreign Exchange trading floor in London, where he worked as a director in Deutsche's FX Complex Risk Group. In late 2005, Cliff resigned from Deutsche to serve as a professor of Computer Science at the University of Southampton. In October 2005 Cliff was appointed Director of a UK national research consortium, addressing issues in the science and engineering of Large-scale Complex IT Systems (LSCITS): this £14m ($28m) research project involved approximately 250 person-years of effort over the years 2007–2014. In July 2007, Cliff moved to become Professor of Computer Science at the University of Bristol.
From 2010 to 2012 Cliff was a member of the 8-person core Lead Expert Group (LEG) which led the UK Government's Government Office for Science two-year investigation into The Future of Computer Trading in Financial Markets. In addition to Cliff, the other members of the LEG were Philip Bond, Clara Furse, Charles Goodhart, Andy Haldane, Kevin Houstoun, Oliver Linton, and Jean-Pierre Zigrand, co-director of the Systemic Risk Centre. The investigation commissioned large volumes of peer-reviewed research from international experts, all of which was published by the Government Office for Science and which is summarised in the project's extensive final report.[20]
In December 2013 Cliff presented a one-off TV documentary on BBC Four titled The Joy of Logic.[22] The programme explored the human quest for certainty and sound reasoning, and the development of logical machines and computers. In April 2015 The Joy of Logic won the top prize - Best International Film - at Europe's leading Science Film Festival, Academia Film Olomouc. It had previously been nominated for international documentary film/TV awards including a "Rockie" at the Banff World Media Festival and a Grierson Award in the UK (losing to Educating Yorkshire).