Dectaflur

Dectaflur
Clinical data
Routes of; administration	Topical (gel, solution)
ATC code	none;
Legal status
Legal status	In general: Over-the-counter (OTC);
Identifiers
	IUPAC name 9-Octadeceylamine hydrofluoride;
CAS Number	7333-84-8 ;
PubChem CID	6433498;
ChemSpider	4938643;
UNII	Q3B1Y93C1S;
ChEMBL	ChEMBL2106567;
CompTox Dashboard (EPA)	DTXSID7073484 ;
ECHA InfoCard	100.297.781
Chemical and physical data
Formula	C18H38FN
Molar mass	287.507 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [F-].C(=C/CCCCCCCC)\CCCCCCCC[NH3+];
	InChI InChI=1S/C18H37N.FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19;/h9-10H,2-8,11-19H2,1H3;1H/b10-9+;; Key:QGSCPWWHMSCFOV-RRABGKBLSA-N;

Dectaflur (INN) is a fluoride-containing substance used for the prevention and treatment of dental caries, sensitive teeth, and the refluoridation of damaged tooth enamel, typically in combination with olaflur.^[1]

Chemistry and mechanism of action

Dectaflur consists of oleyl amine (the amine corresponding to oleyl alcohol) and hydrofluoric acid. Oleyl amine with its long lipophilic hydrocarbon chain has surfactant properties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the top layers of the enamel, reaching a depth of only a few nanometers. The precise mechanism of action is unknown.^[2]

Side effects

Like other fluorides, dectaflur is toxic when overdosed over an extended period of time. Especially in children, before the development of the permanent teeth, overdosage can lead to dental fluorosis.^[3]

References

^ Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Elmex Zahngel. ISBN 978-3-85200-196-8.
^ Müller F, Zeitz C, Mantz H, Ehses KH, Soldera F, Schmauch J, et al. (December 2010). "Elemental depth profiling of fluoridated hydroxyapatite: saving your dentition by the skin of your teeth?". Langmuir. 26 (24): 18750–9. doi:10.1021/la102325e. PMID 21090577.
^ Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL (February 2009). "Dental fluorosis: exposure, prevention and management". Medicina Oral, Patologia Oral y Cirugia Bucal. 14 (2): E103-7. PMID 19179949.

[AustriaCodex-1] Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Elmex Zahngel. ISBN 978-3-85200-196-8.

[2] Müller F, Zeitz C, Mantz H, Ehses KH, Soldera F, Schmauch J, et al. (December 2010). "Elemental depth profiling of fluoridated hydroxyapatite: saving your dentition by the skin of your teeth?". Langmuir. 26 (24): 18750–9. doi:10.1021/la102325e. PMID 21090577.

[3] Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL (February 2009). "Dental fluorosis: exposure, prevention and management". Medicina Oral, Patologia Oral y Cirugia Bucal. 14 (2): E103-7. PMID 19179949.

[1]

[2]

[3]