Edwin Asomaning was born on 21 September 1930 at Sra in Somanya to Charles Kwadwo Asomaning and Matilda Owiredua. His father when he was eleven years of age became Nana Frempong Manso II, Omanhene (Paramount Chief) of the Akim Kotoku Traditional Area in the Eastern Region of Ghana.
Asomaning had his elementary school education at the Presbyterian junior schools in Sra and Akyem Awisa, and in 1942 continued to the Oda Government School where he sat the Middle School Leaving Examination. Asomaning attended the Accra Academy from 1946 to 1950.[1] After this, he worked at the Department of Audit and then the Department of Education as a clerical officer. In 1953,[4] he was granted a scholarship to attend Iowa State University in Ames, where he obtained a Bachelor of Science degree in biology in 1956. He enrolled at Yale University and studied for a master's and a doctoral degree in plant physiology.[1] He undertook post-doctoral work at Long Ashton Research Station in Bristol in the United Kingdom.[1][5]
In 1980, Asomaning was offered an appointment at Cocoa House in Accra as a Special Advisor to the Ghana Cocoa Board (COCOBOD), a position he held for a year before resigning.[1][5] In retirement, he went into private farming and served on the boards of the Ghana Cocoa Board, the Oil Palm Research Institute of Kusi (of which he was chairman) and the Asua Pra Rural Bank of Afosu (only the 3rd rural bank in Ghana at the time). He also was the Ombudsman for the Ghana Oil Palm Development Corporation outgrowers at Kwae in the Eastern Region.[5]