After making only one appearance for Lanús, Tissone was scouted by Italian side Udinese, joining the club in 2005[citation needed] and making 26 Serie A appearances for the club, mainly as a substitute.
Atalanta
On 10 August 2006, Tissone was signed by Atalanta in a co-ownership deal for €1.5 million in a five-year deal.[1][2] However, Udinese also acquired 50% of the registration rights of both Michele Rinaldi for €800,000 and Christian Tiboni for €1.1 million,[1][2] Tissone played 33 games for the Bergamo-based club in 2006–07 Serie A season. In June 2007 the co-ownerships were renewed.
Tissone made 35 appearances in 2007–08 Serie A, missing only three match, including a suspension for a fourth yellow card received.
On 26 June 2008, Tissone returned to Udinese for €4.165 million, with Rinaldi and Tiboni both returning to Atalanta for undisclosed fees (which Atalanta immediately write-down their value).[3][4]
Udinese return
Sampdoria
On 22 July 2009, Tissone joined Sampdoria in a co-ownership from Udinese, for €2.5 million cash and 50% of the registration rights of Jonathan Rossini; Tissone signed four-year contract.[5][6] He remained at the club for two seasons, appearing in 52 league matches and scoring once, against Brescia on 1 May 2011. The co-ownerships were renewed in June 2010[7] and June 2011.[8]
On 31 August 2011, Tissone was loaned to La Liga side Mallorca.[9] He made his debut in the competition on 11 September, coming on as a late substitute in a 1–0 loss at Real Betis.[10]
Tissone featured regularly with the Balearic outfit during the 2011–12 campaign, and returned to Samp in June 2012. In June 2012, Sampdoria acquired Tissone outright from Udinese for an additional €100,000.[11][12] Tissone made 12 appearances in 2012–13 Serie A for Sampdoria
On 29 January 2013, Tissone returned to Mallorca, on loan until June, for €100,000.[13][14][15]
Málaga
After Mallorca's relegation to the Segunda División, Tissone moved to La Liga side Málaga in a three-year deal on 6 July 2013 on a free transfer.[16]
CD Nacional
On 28 September 2018, Tissone signed for Nacional.[17]
Later years
In January 2021, after over a year of inactivity, Tissone signed a six-month contract for Italian Serie D club Taranto, with whom he won promotion to Serie C. He successively joined Serie C club Paganese for the 2021–22 season. In November 2022, Tissone joined Eccellenza Sardinia amateur club Budoni, joining with his brother Cristian,[18] both of them leaving the club just a month later.[19]
On 29 March 2023, both Fernando and Cristian Tissone signed for Eccellenza Marche team Sangiustese.[20]
Tissone's brother, Christian, is also a footballer, but spent the vast majority of his career representing Italian lower division sides, and also switched his nationality to Cape Verde.[23]