In 1860, he returned briefly to Prague. He then spent seven years in Rome; by courtesy of a scholarship. He initially created history paintings, but eventually became associated with the Nazarene movement and devoted himself entirely to religious works. Many of his portraits of saints were stylized after Early Roman and Byzantine models.
He returned to Pilsen in 1868, where he married the daughter of a local pianist, Josef Gerlach. They settled in Prague and he developed a working relationship with the architect, Josef Mocker.
In 1880, he succeeded Jan Swerts as Professor of Religious and History Painting at the Prague Academy. He also served as Rector there for the years 1882 to 1883, 1884 to 1885, 1886 to 1887 and 1890 to 1893. His lectures were very popular. Of his ninety-eight students, the best known include Luděk Marold, František Kupka, Viktor Oliva, Josef Rolletschek [de] and Maxmilián Pirner.
After 1875, he was a member of the Christian Academy and headed the art department there. He was also an active member of the committee for planning the renovation of St. Vitus Cathedral. FFom 1880, he sat on the supervisory commission for the City of Prague Museum. He was elected a member of the Czech Academy of Sciences and Arts [cs] in 1890.
Sequens died on 14 June 1896 in Prague, at the age of 59.
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