GRID1

GRID1
Identifiers
Aliases	GRID1, GluD1, glutamate ionotropic receptor delta type subunit 1, GluD1-b
External IDs	OMIM: 610659; MGI: 95812; HomoloGene: 69017; GeneCards: GRID1; OMA:GRID1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	86,366,795 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	35,305,336 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; C1 segment; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; hypothalamus; ; substantia nigra; ; external globus pallidus; ; Pars compacta; ; amygdala;
	Top expressed in
	Region I of hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; nucleus accumbens; ; dorsomedial hypothalamic nucleus; ; perirhinal cortex; ; entorhinal cortex; ; superior frontal gyrus; ; primary visual cortex; ; lumbar subsegment of spinal cord; ; substantia nigra;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ion channel activity; extracellularly glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity; signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; cell junction; postsynaptic membrane; plasma membrane; synapse; extracellular exosome; membrane; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	social behavior; ion transmembrane transport; ionotropic glutamate receptor signaling pathway; ion transport; excitatory postsynaptic potential; transport; synaptic transmission, glutamatergic; modulation of chemical synaptic transmission; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2894
	14803
	ENSG00000182771
	ENSMUSG00000041078
	Q9ULK0
	Q61627
	NM_017551
	NM_008166
	NP_060021
	NP_032192
	Wikidata
View/Edit Human	View/Edit Mouse

Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein^[5]^[6] (1009 aa) encoded by the GRID1 gene.^[7]^[8] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.^[9]

Function

This gene encodes a subunit of glutamate receptor ligand-gated ion channel. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system^[10] and is important in synaptic plasticity.^[7]^[11]

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.^[12]^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182771 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041078 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochemical and Biophysical Research Communications. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID 1372507.
^ Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics. 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID 9828146.
^ ^a ^b "Entrez Gene: GRID1 glutamate receptor, ionotropic, delta 1".
^ Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
^ Herbrechter R, Hube N, Buchholz R, Reiner A (June 2021). "Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data". Cellular and Molecular Life Sciences. 78 (14): 5605–5630. doi:10.1007/s00018-021-03865-z. PMC 8257547. PMID 34100982.
^ Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, et al. (April 2020). "Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain". The Journal of Comparative Neurology. 528 (6): 1003–1027. doi:10.1002/cne.24792. PMID 31625608. S2CID 203937925.
^ Yuzaki M, Aricescu AR (March 2017). "A GluD Coming-Of-Age Story". Trends in Neurosciences. 40 (3): 138–150. doi:10.1016/j.tins.2016.12.004. PMC 5553105. PMID 28110935.
^ Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, et al. (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophrenia Research. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID 17490860. S2CID 9497500.
^ Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, et al. (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophrenia Research. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID 19346103. S2CID 20949145.